iPTMnet Report for Q9UPT6 (MAPK8IP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPT6 / JIP3_HUMAN
Protein Name C-Jun-amino-terminal kinase-interacting protein 3
Gene Name Name: MAPK8IP3
Synonyms:JIP3,KIAA1066;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPT6
DAG View
PRO Name C-Jun-amino-terminal kinase-interacting protein 3 (human)
Definition A C-Jun-amino-terminal kinase-interacting protein 3 that is encoded in the genome of human.
Short Label hMAPK8IP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPT6 (MAPK8IP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R84 Methylation PhosphoSitePlus
R101 Methylation PhosphoSitePlus
R102 Methylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
T265 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) neXtProt   Signor 15767678, 10523642
T275 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) neXtProt   Signor 15767678, 10523642
T286 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) neXtProt   Signor 15767678, 10523642
S314 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor   UniProt 15767678, 19036714
T362 Phosphorylation PhosphoSitePlus
S364 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor   UniProt 15767678, 19036714
S365 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor   UniProt 15767678, 19036714
S563 O-Glycosylation GlyGen 29351928
S584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S602 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1191 Phosphorylation PhosphoSitePlus
S1260 Phosphorylation PhosphoSitePlus
S1286 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T265 Phosphorylation P45983 (MAPK8) , P53779 (MAPK10) HPRD 10523642, 10629060
T275 Phosphorylation P45983 (MAPK8) , P53779 (MAPK10) HPRD 10523642, 10629060
T286 Phosphorylation P45983 (MAPK8) , P53779 (MAPK10) HPRD 10523642, 10629060
S585 Phosphorylation HPRD 15302935
S676 Phosphorylation HPRD 20068231
T684 Phosphorylation HPRD 20068231
S716 Phosphorylation HPRD 20068231
T913 Phosphorylation HPRD 20068231
S1143 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R101 C101 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T275 M275 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S314 I314 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S563 F563 Biomuta [ cosmic ]
S1143 F1143 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]