iPTMnet Report for Q96ED9 (HOOK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96ED9 / HOOK2_HUMAN
Protein Name Protein Hook homolog 2
Gene Name Name: HOOK2
Organism Homo sapiens (Human)

PRO ID PR:Q96ED9
DAG View
PRO Name protein Hook homolog 2 (human)
Definition A protein Hook homolog 2 that is encoded in the genome of human.
Short Label hHOOK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96ED9 (HOOK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y167 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus   UniProt 23186163
S316 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus   UniProt 24275569
Site PTM Type PTM Enzyme Score Source PMID
S163 Phosphorylation HPRD 18669648
T230 Phosphorylation HPRD 18691976
S316 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S163 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T230 P230 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T230 N230 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S630 F630 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S630 A630 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S665 I665 Biomuta DOID:9256 / colorectal cancer [ cosmic ]