iPTMnet Report for Q8IXZ2 (ZC3H3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IXZ2 / ZC3H3_HUMAN
Protein Name Zinc finger CCCH domain-containing protein 3
Gene Name Name: ZC3H3
Synonyms:KIAA0150,SMICL;
Organism Homo sapiens (Human)

PRO ID PR:Q8IXZ2
DAG View
PRO Name zinc finger CCCH domain-containing protein 3 (human)
Definition A zinc finger CCCH domain-containing protein 3 that is encoded in the genome of human.
Short Label hZC3H3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IXZ2 (ZC3H3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R60 Methylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
C301 Methylation IEDB 31844290
T303 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S408 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
S414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
K460 Acetylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S571 Phosphorylation phospho.ELM 17081983
S584 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
T707 O-Glycosylation GlyGen 30379171
K723 Ubiquitination PhosphoSitePlus
T775 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
R821 Methylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S917 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S918 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S920 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K940 Ubiquitination PhosphoSitePlus
K945 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S207 Phosphorylation HPRD 17924679
S211 Phosphorylation HPRD 20068231, 17924679
T303 Phosphorylation HPRD 18491316
S383 Phosphorylation HPRD 19007248
S408 Phosphorylation HPRD 19651622
S412 Phosphorylation HPRD 17081983
S414 Phosphorylation HPRD 19651622
S569 Phosphorylation HPRD 19007248
S571 Phosphorylation HPRD 18691976, 19007248
S917 Phosphorylation HPRD 18669648
S918 Phosphorylation HPRD 18669648
S920 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S63 F63 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S174 L174 Biomuta DOID:1785 / pituitary cancer [ cosmic ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic ]
S437 L437 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S452 G452 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K519 N519 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K534 R534 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S918 L918 Biomuta DOID:10534 / stomach cancer [ cosmic ]