iPTMnet Report for Q5JTZ9 (AARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JTZ9 / SYAM_HUMAN
Protein Name Alanine--tRNA ligase, mitochondrial precursor
Gene Name Name: AARS2
Synonyms:AARSL,KIAA1270;
Organism Homo sapiens (Human)

PRO ID PR:Q5JTZ9
DAG View
PRO Name alanine--tRNA ligase, mitochondrial (human)
Definition An alanine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hAARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JTZ9 (AARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K83 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
R561 Methylation PhosphoSitePlus
R575 Methylation PhosphoSitePlus
R580 Methylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus 18847512
T673 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S712 Phosphorylation HPRD   PhosphoSitePlus 20068231
S795 O-Glycosylation GlyGen 23301498, 31492838, 28510447, ...34229054
K801 Ubiquitination PhosphoSitePlus
R819 Methylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S361 F361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
R580 Q580 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R580 W580 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S894 L894 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]