iPTMnet Report for Q5JTZ9 (AARS2)
Protein Information
UniProt AC / UniProt ID | Q5JTZ9 / SYAM_HUMAN |
Protein Name | Alanine--tRNA ligase, mitochondrial precursor |
Gene Name | Name: AARS2 Synonyms:AARSL,KIAA1270; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q5JTZ9 |
PRO Name | alanine--tRNA ligase, mitochondrial (human) |
Definition | An alanine--tRNA ligase, mitochondrial that is encoded in the genome of human. |
Short Label | hAARS2 |
Category | organism-gene |
Q5JTZ9 (AARS2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K83 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
S361 | Phosphorylation | score1 | PhosphoSitePlus | |||
S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
T382 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y387 | Phosphorylation | score1 | PhosphoSitePlus | |||
S402 | Phosphorylation | score1 | PhosphoSitePlus | |||
R561 | Methylation | score1 | PhosphoSitePlus | |||
R575 | Methylation | score1 | PhosphoSitePlus | |||
R580 | Methylation | score1 | PhosphoSitePlus | |||
T673 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
S712 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S795 | O-Glycosylation | score1 | GlyGen | 23301498, 31492838, 28510447, ... | ||
K801 | Ubiquitination | score1 | PhosphoSitePlus | |||
R819 | Methylation | score1 | PhosphoSitePlus | |||
T857 | Phosphorylation | score1 | PhosphoSitePlus | |||
S892 | Phosphorylation | score1 | PhosphoSitePlus | |||
S894 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S361 | F361 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] | |
R580 | Q580 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
R580 | W580 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S894 | L894 | Biomuta | DOID:1612 / breast cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] |