iPTMnet Report Q08431 MFGE8

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q08431 / MFGM_HUMAN
Protein Name	Lactadherin precursor
Gene Name	Name: MFGE8
Organism	Homo sapiens (Human)

PRO ID	PR:Q08431 DAG View
PRO Name	lactadherin (human)
Definition	A lactadherin that is encoded in the genome of human.
Short Label	hMFGE8
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q08431 (MFGE8) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S42	Phosphorylation		score2	PhosphoSitePlus UniProt	26091039
	K59	Ubiquitination		score1	PhosphoSitePlus
	K69	Ubiquitination		score1	PhosphoSitePlus
	K156	Ubiquitination		score1	PhosphoSitePlus
	N228	N-Glycosylation		score2	GlyGen UniProt	18780401
	N238	N-Glycosylation		score2	GlyGen UniProt	29741879, 32125861, 18780401
	S240	O-Glycosylation		score1	GlyGen	35289036
	T247	Phosphorylation		score1	PhosphoSitePlus
	S249	Phosphorylation		score1	PhosphoSitePlus
	S250	Phosphorylation		score1	PhosphoSitePlus
	Y252	Phosphorylation		score1	PhosphoSitePlus
	N285	N-Glycosylation		score1	GlyGen	24190977
	N325	N-Glycosylation		score2	GlyGen UniProt	23090970, 29741879, 24190977, ...32125861, 18780401
	N329	N-Glycosylation		score2	GlyGen UniProt	23090970, 24190977, 32125861, ...18780401
	N350	N-Glycosylation		score2	GlyGen UniProt	18780401

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S42	Phosphorylation		score0	HPRD	18077418
	N238	N-Glycosylation		score1	PRO	29741879
	T247	Phosphorylation		score0	HPRD	20166139
	S249	Phosphorylation		score0	HPRD	20166139
	S250	Phosphorylation		score0	HPRD	20166139
	Y252	Phosphorylation		score0	HPRD	20166139

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T247	M247	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
T247	K247	Biomuta		DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S249	F249	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
S250	G250	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]