iPTMnet Report for Q08431 (MFGE8)
Protein Information
UniProt AC / UniProt ID | Q08431 / MFGM_HUMAN |
Protein Name | Lactadherin precursor |
Gene Name | Name: MFGE8 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q08431 |
PRO Name | lactadherin (human) |
Definition | A lactadherin that is encoded in the genome of human. |
Short Label | hMFGE8 |
Category | organism-gene |
Q08431 (MFGE8) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S42 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 26091039 | ||
K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
N228 | N-Glycosylation | score2 | GlyGen UniProt | 18780401 | ||
N238 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 32125861, 18780401 | ||
S240 | O-Glycosylation | score1 | GlyGen | 35289036 | ||
T247 | Phosphorylation | score1 | PhosphoSitePlus | |||
S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
S250 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y252 | Phosphorylation | score1 | PhosphoSitePlus | |||
N285 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
N325 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 29741879, 24190977, ... | ||
N329 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 24190977, 32125861, ... | ||
N350 | N-Glycosylation | score2 | GlyGen UniProt | 18780401 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T247 | M247 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T247 | K247 | Biomuta | DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
S249 | F249 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S250 | G250 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |