iPTMnet Report for P38936 (CDKN1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P38936 / CDN1A_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 1
Gene Name Name: CDKN1A
Synonyms:CAP20,CDKN1,CIP1,MDA6,PIC1,SDI1,WAF1;
Organism Homo sapiens (Human)

PRO ID PR:P38936
DAG View
PRO Name cyclin-dependent kinase inhibitor 1 (human)
Definition A cyclin-dependent kinase inhibitor 1 that is encoded in the genome of human.
Short Label hCDKN1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38936 (CDKN1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15574338
S15 Phosphorylation RLIMS-P 24928858, 30272263, 18852884
K16 Ubiquitination PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
C34 Methylation IEDB 31844290
C41 Methylation IEDB 31844290
T55 Phosphorylation PhosphoSitePlus
T57 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) , P45983 (MAPK8) , P49841 (GSK3B) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19822666, 12058028, 11779850, ...23745637, 19364816, 15798220
K75 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus   UniProt 25329316
S98 Phosphorylation Q99683 (MAP3K5) , P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 17325029
S114 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17283049, 18794347
S116 Phosphorylation RLIMS-P 24136223
S123 Phosphorylation PhosphoSitePlus
S130 Phosphorylation Q00534 (CDK6) , Q16539 (MAPK14) , P45983 (MAPK8) , P24941 (CDK2) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22227330, 15964852, 16508017, ...12058028, 27384476, 19664994, 12730199, 18669648, 34913830, 19364816, 27909065, 16964243
S137 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T145 Phosphorylation P31749 (AKT1) , O14757 (CHEK1) , Q9P1W9 (PIM2) , P11309 (PIM1) , O43293 (DAPK3) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10753973, 11231573, 16982699, ...12431783, 11756412, 28235398, 36147919, 20444901, 34069970, 24136223, 31495718, 15001356, 33147101, 17460069, 26436589, 15173090, 25486478, 20307683, 24848107, 24291038, 11463845, 17855660
S146 Phosphorylation Q05655 (PRKCD) , P53355 (DAPK1) , O14757 (CHEK1) , P11309 (PIM1) , Q9NRM7 (LATS2) , Q9P1W9 (PIM2) , P17252 (PRKCA) , P16885 (PLCG2) , P19174 (PLCG1) , P31749 (AKT1) , Q15208 (STK38) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10753973, 33147101, 17297916, ...23886938, 31575057, 17431791, 11756412, 24136223, 12897801, 21262772, 31495718, 24291038, 25486478, 25329316, 12485998, 17855660, 20307683
Y151 Phosphorylation PhosphoSitePlus
S153 Phosphorylation P17252 (PRKCA) , Q9Y463 (DYRK1B) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16055744, 15851482, 16357525
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
R156 Methylation PhosphoSitePlus
S160 Phosphorylation UniProt 10753973
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046680 (hCDKN1A/InitMet-/Phos:2) pS130 PRO
PR:000046681 (hCDKN1A/InitMet-/Phos:3) pT145 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06493 (CDK1) T161 P38936 (CDKN1A) increased_association eFIP 15798220
Phosphorylation P38936 (CDKN1A) S146 P12004 (PCNA) inhibited_association eFIP 11756412