iPTMnet Report for P38936 (CDKN1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P38936 / CDN1A_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 1
Gene Name Name: CDKN1A
Synonyms:CAP20,CDKN1,CIP1,MDA6,PIC1,SDI1,WAF1;
Organism Homo sapiens (Human)

PRO ID PR:P38936
DAG View
PRO Name cyclin-dependent kinase inhibitor 1 (human)
Definition A cyclin-dependent kinase inhibitor 1 that is encoded in the genome of human.
Short Label hCDKN1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38936 (CDKN1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15574338
S15 Phosphorylation RLIMS-P 24928858, 30272263, 18852884
K16 Ubiquitination PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
C34 Methylation IEDB 31844290
C41 Methylation IEDB 31844290
T55 Phosphorylation PhosphoSitePlus
T57 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19822666, 12058028, 11779850, ...23745637, 19364816, 15798220
T57 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19364816
T57 Phosphorylation P45983 (MAPK8) HPRD   neXtProt   PhosphoSitePlus 12058028, 19822666
T57 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 11779850
T57 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 12058028
K75 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus   UniProt 25329316
S98 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 17325029
S98 Phosphorylation P45983 (MAPK8) RLIMS-P+ 17325029
S98 Phosphorylation Q99683 (MAP3K5) phospho.ELM   PhosphoSitePlus   Signor 17325029
S114 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17283049, 18794347
S114 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 17283049
S116 Phosphorylation RLIMS-P 24136223
S123 Phosphorylation PhosphoSitePlus
S130 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22227330, 15964852, 16508017, ...12058028, 27384476, 19664994, 12730199, 18669648, 34913830, 19364816, 27909065, 16964243
S130 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 12730199, 15964852
S130 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 19364816
S130 Phosphorylation P45983 (MAPK8) HPRD   neXtProt   PhosphoSitePlus   Signor 12058028, 19664994, 18669648, ...16964243
S130 Phosphorylation Q00534 (CDK6) neXtProt   PhosphoSitePlus   Signor 16508017
S130 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 12058028
S137 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T145 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10753973, 11231573, 16982699, ...12431783, 11756412, 28235398, 36147919, 20444901, 34069970, 24136223, 31495718, 15001356, 33147101, 17460069, 26436589, 15173090, 25486478, 20307683, 24848107, 24291038, 11463845, 17855660
T145 Phosphorylation O14757 (CHEK1) RLIMS-P+ 25486478
T145 Phosphorylation O43293 (DAPK3) HPRD   neXtProt   PhosphoSitePlus 15001356
T145 Phosphorylation P11309 (PIM1) HPRD   neXtProt   PhosphoSitePlus   Signor 12431783, 17855660, 20307683
T145 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   Signor 11231573, 16982699, 15173090, ...11756412, 11463845, 17855660
T145 Phosphorylation Q9P1W9 (PIM2) neXtProt   PhosphoSitePlus   Signor 20307683
S146 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10753973, 33147101, 17297916, ...23886938, 31575057, 17431791, 11756412, 24136223, 12897801, 21262772, 31495718, 24291038, 25486478, 25329316, 12485998, 17855660, 20307683
S146 Phosphorylation O14757 (CHEK1) RLIMS-P+ 25486478
S146 Phosphorylation P11309 (PIM1) PhosphoSitePlus   Signor 17855660, 31575057
S146 Phosphorylation P16885 (PLCG2) Signor 31575057
S146 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 10753973
S146 Phosphorylation P19174 (PLCG1) Signor 31575057
S146 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   Signor 11756412, 31575057
S146 Phosphorylation P53355 (DAPK1) neXtProt 17297916
S146 Phosphorylation Q05655 (PRKCD) neXtProt 17431791
S146 Phosphorylation Q15208 (STK38) neXtProt   Signor 21262772
S146 Phosphorylation Q9NRM7 (LATS2) neXtProt   PhosphoSitePlus 23886938
S146 Phosphorylation Q9P1W9 (PIM2) PhosphoSitePlus 20307683
Y151 Phosphorylation PhosphoSitePlus
S153 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16055744, 15851482, 16357525
S153 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 16055744
S153 Phosphorylation Q9Y463 (DYRK1B) neXtProt   phospho.ELM   PhosphoSitePlus 15851482
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
R156 Methylation PhosphoSitePlus
S160 Phosphorylation UniProt 10753973
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046680 (hCDKN1A/InitMet-/Phos:2) pS130 PRO
PR:000046681 (hCDKN1A/InitMet-/Phos:3) pT145 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06493 (CDK1) T161 P38936 (CDKN1A) increased_association eFIP 15798220
Phosphorylation P38936 (CDKN1A) S146 P12004 (PCNA) inhibited_association eFIP 11756412