iPTMnet Report for P25398 (RPS12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25398 / RS12_HUMAN
Protein Name Small ribosomal subunit protein eS12
Gene Name Name: RPS12
Organism Homo sapiens (Human)

PRO ID PR:P25398
DAG View
PRO Name 40S ribosomal protein S12 (human)
Definition A 40S ribosomal protein S12 that is encoded in the genome of human.
Short Label hRPS12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25398 (RPS12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 20068231, 22814378, ...22223895, 25944712
K23 Ubiquitination PhosphoSitePlus
T24 Phosphorylation HPRD   PhosphoSitePlus 20068231
R33 Methylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
C92 Methylation IEDB 31844290
C92 S-Nitrosylation dbSNO 26338901
K93 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S107 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 21740066, 33465208, 34019948, 35083852, 32870666, 28510447, 22121020, 34229054
S107 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K129 Methylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y61 C61 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y61 F61 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K84 T84 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K99 N99 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S118 Y118 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K121 N121 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]