iPTMnet Report for P24864 (CCNE1)
Protein Information
UniProt AC / UniProt ID | P24864 / CCNE1_HUMAN |
Protein Name | G1/S-specific cyclin-E1 |
Gene Name | Name: CCNE1 Synonyms:CCNE; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P24864 |
PRO Name | G1/S-specific cyclin-E1 (human) |
Definition | A G1/S-specific cyclin-E1 that is encoded in the genome of human. |
Short Label | hCCNE1 |
Category | organism-gene |
P24864 (CCNE1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S59 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
S73 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 14536078 | |
T77 | Phosphorylation | P49841 (GSK3B) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 14536078, 17434132, 15364936 | |
S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
S103 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 15364936, 23186163, ... | ||
S366 | Phosphorylation | score0 | RLIMS-P | 29760377 | ||
S381 | Phosphorylation | score1 | PhosphoSitePlus | |||
S387 | Phosphorylation | P24941 (CDK2) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 18691976, 23186163, 19369195, ... | |
S391 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
T395 | Phosphorylation | P49840 (GSK3A) , P49841 (GSK3B) , P24941 (CDK2) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 17434132, 19561641, 14536078, ... | |
S399 | Phosphorylation | P24941 (CDK2) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 14536078, 17218276, 17434132, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S59 | Phosphorylation | score0 | HPRD | 17525332 | ||
T77 | Phosphorylation | score1 | HPRD | 14536078 | ||
S100 | Phosphorylation | score0 | HPRD | 18691976 | ||
S103 | Phosphorylation | score0 | HPRD | 18691976, 19664994 | ||
S381 | Phosphorylation | score0 | HPRD | 18691976 | ||
S387 | Phosphorylation | score2 | HPRD | 14536078, 18691976, 18669648 | ||
S391 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
T395 | Phosphorylation | P49841 (GSK3B) | score2 | HPRD | 14536078, 18691976, 8861947 | |
S399 | Phosphorylation | P24941 (CDK2) | score2 | HPRD | 14536078, 18691976 |
P24864 (CCNE1) as PTM Enzyme
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000025637 (hCCNE1/iso:3/Phos:1) | pS384 | PRO | 16223725 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P24864 (CCNE1) | S366 | P24941 (CDK2) | inhibited_association | eFIP | 29760377 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000025637 (hCCNE1/iso:3/Phos:1) | Interaction | PR:Q13526 (hPIN1) | PRO | 16223725 | |
PR:000025750 (hCDKN1B/iso:1/Phos:2) | Interaction | PR:P24864 (hCCNE1) | PRO | 17254966 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S90 | L90 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S381 | C381 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S384 | I384 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
S384 | R384 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S391 | R391 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T395 | P395 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] | |
T395 | I395 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] | |
S399 | I399 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
S399 | R399 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |