iPTMnet Report for P24864 (CCNE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P24864 / CCNE1_HUMAN
Protein Name G1/S-specific cyclin-E1
Gene Name Name: CCNE1
Synonyms:CCNE;
Organism Homo sapiens (Human)

PRO ID PR:P24864
DAG View
PRO Name G1/S-specific cyclin-E1 (human)
Definition A G1/S-specific cyclin-E1 that is encoded in the genome of human.
Short Label hCCNE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24864 (CCNE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S73 Phosphorylation PhosphoSitePlus 14536078
S73 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 14536078
T77 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 14536078, 17434132, 15364936
T77 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 14536078
S90 Phosphorylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 15364936, 23186163, ...19369195
S366 Phosphorylation RLIMS-P 29760377
S381 Phosphorylation PhosphoSitePlus
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 23186163, 19369195, ...19561641, 15364936, 14536078, 18669648
S387 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 14536078, 19561641
S391 Phosphorylation phospho.ELM 18669648
T395 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 17434132, 19561641, 14536078, ...18691976, 8861947
T395 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 14536078, 8861947, 19561641
T395 Phosphorylation P49840 (GSK3A) PhosphoSitePlus 14536078
T395 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 14536078
S399 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14536078, 17218276, 17434132, ...22558078
S399 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 14536078, 17218276
Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation HPRD 17525332
T77 Phosphorylation HPRD 14536078
S100 Phosphorylation HPRD 18691976
S103 Phosphorylation HPRD 18691976, 19664994
S381 Phosphorylation HPRD 18691976
S387 Phosphorylation HPRD 14536078, 18691976, 18669648
S391 Phosphorylation HPRD 18691976, 18669648
T395 Phosphorylation HPRD 14536078, 18691976, 8861947
T395 Phosphorylation P49841 (GSK3B) HPRD 14536078, 18691976, 8861947
S399 Phosphorylation HPRD 14536078, 18691976
S399 Phosphorylation P24941 (CDK2) HPRD 14536078, 18691976
Site PTM Type PTM Enzyme Score Source PMID
S384 Phosphorylation PRO 16223725


P24864 (CCNE1) as PTM Enzyme



Substrate Site Score Source PMID
Q8TDN4-2 (CABLES1) S48 HPRD 11733001, 18691976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025637 (hCCNE1/iso:3/Phos:1) pS384 PRO 16223725


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P24864 (CCNE1) S366 P24941 (CDK2) inhibited_association eFIP 29760377


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025637 (hCCNE1/iso:3/Phos:1) Interaction PR:Q13526 (hPIN1) PRO 16223725
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24864 (hCCNE1) PRO 17254966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S90 L90 Biomuta DOID:363 / uterine cancer [ icgc ]
S381 C381 Biomuta DOID:1324 / lung cancer [ cosmic ]
S384 I384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S384 R384 Biomuta DOID:1324 / lung cancer [ cosmic ]
S391 R391 Biomuta DOID:1324 / lung cancer [ cosmic ]
T395 P395 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T395 I395 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S399 I399 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S399 R399 Biomuta DOID:1324 / lung cancer [ cosmic ]