iPTMnet Report P04278 SHBG

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P04278 / SHBG_HUMAN
Protein Name	Sex hormone-binding globulin precursor
Gene Name	Name: SHBG
Organism	Homo sapiens (Human)

PRO ID	PR:P04278 DAG View
PRO Name	sex hormone-binding globulin (human)
Definition	A sex hormone-binding globulin that is encoded in the genome of human.
Short Label	hSHBG
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P04278 (SHBG) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S3	Phosphorylation		score1	PhosphoSitePlus
	T36	O-Glycosylation		score3	GlyGen	6684483, 30459171, 1400872, ...23001782
	S72	Phosphorylation		score1	PhosphoSitePlus
	T161	Phosphorylation		score1	PhosphoSitePlus
	S162	Phosphorylation		score1	PhosphoSitePlus
	N380	N-Glycosylation		score4	GlyGen UniProt	16335952, 3542030, 19159218, ...23090970, 23001782, 6684483, 29741879, 29671580
	N396	N-Glycosylation		score4	GlyGen UniProt	34725484, 3542030, 23090970, ...23001782, 6684483, 29741879, 29671580, 1400872

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y86	Phosphorylation		score0	HPRD	17322306
	N380	N-Glycosylation		score3	PRO	6684483, 29671580, 23001782
	N396	N-Glycosylation		score3	PRO	6684483, 29671580, 23001782

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S3	N3	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
Y86	F86	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]