iPTMnet Report for O76070 (SNCG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76070 / SYUG_HUMAN
Protein Name Gamma-synuclein
Gene Name Name: SNCG
Synonyms:BCSG1,PERSYN,PRSN;
Organism Homo sapiens (Human)

PRO ID PR:O76070
DAG View
PRO Name gamma-synuclein (human)
Definition A gamma-synuclein that is encoded in the genome of human.
Short Label hSNCG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76070 (SNCG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Methylation PhosphoSitePlus
K6 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
T27 O-Glycosylation GlyGen 28657654
Y39 Phosphorylation PhosphoSitePlus
T44 O-Glycosylation GlyGen 28657654, 22661428, 35254053
T44 Phosphorylation PhosphoSitePlus
S51 Phosphorylation HPRD   PhosphoSitePlus 20068231
T53 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S54 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S54 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
T59 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S67 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S72 O-Glycosylation GlyGen 28657654, 22661428, 35254053
T81 O-Glycosylation GlyGen 28657654, 22661428, 35254053
T91 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S92 O-Glycosylation GlyGen 28657654, 22661428, 35254053
S112 Phosphorylation PhosphoSitePlus
S124 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10852916, 18669648
S124 Phosphorylation P34947 (GRK5) HPRD   neXtProt 10852916, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T27 M27 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y39 C39 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]