[Term]
id: PR:000050312
name: IgG4 immunoglobulin complex, circulating (human)
def: "An IgG4 immunoglobulin complex (human) that is composed of two immunoglobulin heavy chains of an IgG4 isotype of the secretory isoform and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "hIgG4/circulating" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG4 antibody (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050308 ! IgG4 immunoglobulin complex (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050300 {cardinality="2"} ! IgG4 heavy chain protein, secretory isoform (human)

[Term]
id: PR:000050308
name: IgG4 immunoglobulin complex (human)
def: "An IgG immunoglobulin complex that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:19222496, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note: An IgG4 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hIgG4" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG4 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "IgG4 antibody (human)" NARROW [PRO:ADD, GOC:add]
is_a: GO:0071735 ! IgG immunoglobulin complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050294 {cardinality="2"} ! IgG4 heavy chain protein (human)

[Term]
id: PR:000050316
name: IgG4 B cell receptor complex (human)
def: "An IgG4 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG4 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "surface IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "surface IgG4 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hIgG4/B-cell-receptor" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG4 (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050308 ! IgG4 immunoglobulin complex (human)
relationship: part_of CL:0000236 ! B cell
relationship: part_of GO:0005886 ! plasma membrane
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050304 {cardinality="2"} ! IgG4 heavy chain protein, membrane-bound isoform (human)
relationship: has_component PR:P11912 {cardinality="1"} ! B-cell antigen receptor complex-associated protein alpha chain (human)
relationship: has_component PR:P40259 {cardinality="1"} ! B-cell antigen receptor complex-associated protein beta chain (human)