[Term]
id: PR:000050311
name: IgG3 immunoglobulin complex, circulating (human)
def: "An IgG3 immunoglobulin complex (human) that is composed of two identical immunoglobulin heavy chains of an IgG3 isotype of the secretory isoform and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "hIgG3/circulating" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG3 antibody (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050307 ! IgG3 immunoglobulin complex (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050299 {cardinality="2"} ! IgG3 heavy chain protein, secretory isoform (human)

[Term]
id: PR:000050307
name: IgG3 immunoglobulin complex (human)
def: "An IgG immunoglobulin complex that is composed of two identical immunoglobulin heavy chains of an IgG3 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG3 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note: An IgG3 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hIgG3" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG3 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "IgG3 antibody (human)" NARROW [PRO:ADD, GOC:add]
is_a: GO:0071735 ! IgG immunoglobulin complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050293 {cardinality="2"} ! IgG3 heavy chain protein (human)

[Term]
id: PR:000050315
name: IgG3 B cell receptor complex (human)
def: "An IgG3 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG3 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "surface IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "surface IgG3 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hIgG3/B-cell-receptor" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG3 (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050307 ! IgG3 immunoglobulin complex (human)
relationship: part_of CL:0000236 ! B cell
relationship: part_of GO:0005886 ! plasma membrane
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050303 {cardinality="2"} ! IgG3 heavy chain protein, membrane-bound isoform (human)
relationship: has_component PR:P11912 {cardinality="1"} ! B-cell antigen receptor complex-associated protein alpha chain (human)
relationship: has_component PR:P40259 {cardinality="1"} ! B-cell antigen receptor complex-associated protein beta chain (human)