[Term]
id: PR:000050306
name: IgG2 immunoglobulin complex (human)
def: "An IgG immunoglobulin complex that is composed of two identical immunoglobulin heavy chains of an IgG2 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG2 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note: An IgG2 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hIgG2" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG2 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "IgG2 antibody (human)" NARROW [PRO:ADD, GOC:add]
is_a: GO:0071735 ! IgG immunoglobulin complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050292 {cardinality="2"} ! IgG2 heavy chain protein (human)

[Term]
id: PR:000050310
name: IgG2 immunoglobulin complex, circulating (human)
def: "An IgG2 immunoglobulin complex (human) that is composed of two identical immunoglobulin heavy chains of an IgG2 isotype of the secretory isoform and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "hIgG2/circulating" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "IgG antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgG2 antibody (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050306 ! IgG2 immunoglobulin complex (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050298 {cardinality="2"} ! IgG2 heavy chain protein, secretory isoform (human)

[Term]
id: PR:000050314
name: IgG2 B cell receptor complex (human)
def: "An IgG2 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG2 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.
synonym: "surface IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "surface IgG2 (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hIgG2/B-cell-receptor" EXACT PRO-short-label [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG (human)" BROAD [PRO:ADD, GOC:add]
synonym: "membrane-bound IgG2 (human)" EXACT [PRO:ADD, GOC:add]
is_a: PR:000050306 ! IgG2 immunoglobulin complex (human)
relationship: part_of CL:0000236 ! B cell
relationship: part_of GO:0005886 ! plasma membrane
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000050183 {cardinality="2"} ! immunoglobulin light chain protein (human)
relationship: has_component PR:000050302 {cardinality="2"} ! IgG2 heavy chain protein, membrane-bound isoform (human)
relationship: has_component PR:P11912 {cardinality="1"} ! B-cell antigen receptor complex-associated protein alpha chain (human)
relationship: has_component PR:P40259 {cardinality="1"} ! B-cell antigen receptor complex-associated protein beta chain (human)