[Term]
id: PR:000037446
name: MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
def: "A MYD88:TIRAP:PIP2:BTK:activated TLR4 complex that is composed of MyD88, PI(4,5)P2, TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human." [PMID:12888566, PMID:21873236, Reactome:R-HSA-166062]
comment: Category=organism-complex.
synonym: "MyD88:MAL:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-166062]
synonym: "MyD88:Mal complexed with the activated TLR (human)" RELATED [Reactome:R-HSA-166062]
is_a: PR:000037488 ! MYD88:TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027214 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human)
relationship: has_component PR:000044351 {cardinality="2"} ! tyrosine-protein kinase BTK, initiator methionine removed form (human)
relationship: has_component PR:Q99836 {cardinality="2"} ! myeloid differentiation primary response protein MyD88 (human)