[Term]
id: PR:000036052
name: IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, and the IKK complex (consisting of IKKA, IKKB and NEMO)." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex" EXACT [Reactome:R-HSA-937030]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000036053
name: IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
def: "An IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)" EXACT [Reactome:R-HSA-937030]
is_a: PR:000036052 ! IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035702 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)
relationship: has_component PR:000036051 {cardinality="2"} ! receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:O14920 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: has_component PR:O15111 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: has_component PR:Q9Y6K9 {cardinality="1"} ! NF-kappa-B essential modulator (human)