[Term]
id: PR:000036030
name: IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
def: "An IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000036029 ! IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028695 {cardinality="2"} ! serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
relationship: has_component PR:000028702 {cardinality="2"} ! interferon regulatory factor 3 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)