[Term]
id: PR:000036029
name: IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated tbk1, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated tbk1." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3" RELATED [Reactome:REACT_27000]
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex