[Term]
id: PR:000030938
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
def: "A protein that is a translation product of the human MTHFD2L gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFD2L" EXACT PRO-short-label [PRO:DNx]
synonym: "MTHFD2-like" EXACT []
synonym: "NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein" EXACT []
synonym: "probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:D3ZUA0-2
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform r2 (rat)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D3ZUA0-2." [PRO:DNx, UniProtKB:D3ZUA0]
comment: Category=organism-sequence.
synonym: "rMTHFD2L/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:D3ZUA0-2
is_a: PR:D3ZUA0 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:D3ZUA0-1
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform r1 (rat)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D3ZUA0-1." [PRO:DNx, UniProtKB:D3ZUA0]
comment: Category=organism-sequence.
synonym: "rMTHFD2L/iso:r1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:D3ZUA0-1
is_a: PR:D3ZUA0 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q9H903-1
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform h1 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H903-1." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-sequence.
synonym: "hMTHFD2L/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H903-1
is_a: PR:Q9H903 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9H903-2
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform h2 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H903-2." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-sequence.
synonym: "hMTHFD2L/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H903-2
is_a: PR:Q9H903 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9H903-3
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform h3 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H903-3." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-sequence.
synonym: "hMTHFD2L/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H903-3
is_a: PR:Q9H903 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9H903-4
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform h4 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H903-4." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-sequence.
synonym: "hMTHFD2L/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H903-4
is_a: PR:Q9H903 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9H903
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-gene.
synonym: "MTHFD2L" RELATED Gene-based [UniProtKB:Q9H903]
synonym: "hMTHFD2L" EXACT PRO-short-label [PRO:DNx]
synonym: "MTHFD2-like (human)" EXACT [UniProtKB:Q9H903]
synonym: "NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (human)" EXACT [UniProtKB:Q9H903]
xref: UniProtKB:Q9H903
xref: Reactome:R-HSA-6801350 "PR:Q9H903 located_in GO:0005759"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030938 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
relationship: has_gene_template HGNC:31865 ! MTHFD2L (human)

[Term]
id: PR:D3ZUA0
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (rat)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial that is encoded in the genome of rat." [OMA:D3ZUA0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mthfd2l" RELATED Gene-based [UniProtKB:D3ZUA0]
synonym: "rMTHFD2L" EXACT PRO-short-label [PRO:DNx]
synonym: "MTHFD2-like (rat)" EXACT [UniProtKB:D3ZUA0]
synonym: "NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (rat)" EXACT [UniProtKB:D3ZUA0]
xref: UniProtKB:D3ZUA0
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000030938 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
relationship: has_gene_template RGD:1310879 ! Mthfd2l (rat)

[Term]
id: PR:D3YZG8
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (mouse)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial that is encoded in the genome of mouse." [OMA:D3YZG8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mthfd2l" RELATED Gene-based [UniProtKB:D3YZG8]
synonym: "mMTHFD2L" EXACT PRO-short-label [PRO:DNx]
synonym: "MTHFD2-like (mouse)" EXACT [UniProtKB:D3YZG8]
synonym: "NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (mouse)" EXACT [UniProtKB:D3YZG8]
xref: UniProtKB:D3YZG8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000030938 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
relationship: has_gene_template MGI:1915871 ! Mthfd2l (mouse)

[Term]
id: PR:Q9H903-5
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform h5 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H903-5." [PRO:DNx, UniProtKB:Q9H903]
comment: Category=organism-sequence.
synonym: "hMTHFD2L/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H903-5
is_a: PR:Q9H903 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens