[Term]
id: PR:000030035
name: G-protein coupled receptor
def: "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." [IUPHARfam:694, PRO:DAN, Wikipedia:GPCR]
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]
synonym: "fam:GPCR" EXACT PRO-short-label [PRO:DAN]
synonym: "7TM receptor" BROAD [IUPHARfam:694]
synonym: "seven-transmembrane receptor" BROAD [IUPHARfam:694]
xref: IUPHARfam:694
intersection_of: capable_of GO:0004930 ! G protein-coupled receptor activity
intersection_of: PR:000000001 ! protein