[Term]
id: PR:000029187
name: ribosomal protein S6 kinase alpha
def: "A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433) and another copy of the a Protein kinase domain (Pfam:PF00069). Prototype members of this class act downstream of ERK1/2 signaling pahtway. There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations." [PMID:10411321, PRO:CNA]
comment: Category=family.
synonym: "p90RSK" EXACT [PMID:19915011]
synonym: "MAPKAP-K1" EXACT [PMID:10411321]
synonym: "p90 ribosomal S6 kinase" EXACT [PMID:19915011]
synonym: "ribosomal protein S6 kinase II" EXACT [PIRSF:PIRSF000606]
synonym: "MAPK-activated protein kinase-1" EXACT [PMID:10411321]
xref: PIRSF:PIRSF000606
is_a: PR:000000001 ! protein