[Term]
id: PR:O08586
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (mouse)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of mouse." [OMA:O08586, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pten" RELATED Gene-based [UniProtKB:O08586]
synonym: "Mmac1" RELATED Gene-based [UniProtKB:O08586]
synonym: "mPTEN" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatase and tensin homolog (mouse)" EXACT [UniProtKB:O08586]
synonym: "mutated in multiple advanced cancers 1 (mouse)" EXACT [UniProtKB:O08586]
xref: UniProtKB:O08586
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028746 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
relationship: has_gene_template MGI:109583 ! Pten (mouse)

[Term]
id: PR:000028747
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P60484-1 or a 1:1 ortholog thereof." [PMID:18757404, PRO:PD]
comment: Category=sequence.
synonym: "PTEN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028746 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

[Term]
id: PR:000048943
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ubiquitinated form (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that includes at least one ubiquitinated lysine. UniProtKB:P60484, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782515]
comment: Category=organism-modification.
synonym: "hPTEN/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60484, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782515 "PR:000048943 located_in GO:0005654"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P60484
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of human." [PRO:PD, UniProtKB:P60484]
comment: Category=organism-gene.
synonym: "PTEN" RELATED Gene-based [UniProtKB:P60484]
synonym: "TEP1" RELATED Gene-based [UniProtKB:P60484]
synonym: "MMAC1" RELATED Gene-based [UniProtKB:P60484]
synonym: "hPTEN" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatase and tensin homolog (human)" EXACT [UniProtKB:P60484]
synonym: "mutated in multiple advanced cancers 1 (human)" EXACT [UniProtKB:P60484]
xref: Reactome:R-HSA-5690148 "PR:P60484 located_in GO:0005654"
xref: UniProtKB:P60484
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028746 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
relationship: has_gene_template HGNC:9588 ! PTEN (human)

[Term]
id: PR:P60484-2
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform alpha (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P60484-2." [PRO:DNx, UniProtKB:P60484]
comment: Category=organism-sequence.
synonym: "hPTEN/iso:alpha" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 70kDa (human)" EXACT [UniProtKB:P60484]
synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN-long (human)" EXACT [UniProtKB:P60484]
xref: UniProtKB:P60484-2
is_a: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028750
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 1 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 1 in human. Acetylation within the PDZ domain alters PTEN interaction with PDZ domain-containing proteins, and thus may modulate PTEN function. UniProtKB:P60484-1, Lys-402, MOD:00064." [PMID:18757404, PRO:PD]
comment: Category=organism-modification. Acetylase=("CREBBP"; PR:Q92793).
synonym: "hPTEN/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60484-1, Lys-402, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028749 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028746
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
def: "A protein that is a translation product of the human PTEN gene or a 1:1 ortholog thereof." [PMID:18757404, PRO:PD]
comment: Category=gene.
synonym: "PTEN" EXACT PRO-short-label [PRO:DNx]
synonym: "TEP1" RELATED Gene-based []
synonym: "MMAC1" RELATED Gene-based []
synonym: "Phosphatase and tensin homolog" EXACT []
synonym: "Mutated in multiple advanced cancers 1" EXACT []
xref: IUPHARobj:2497
is_a: PR:000000001 ! protein

[Term]
id: PR:000028749
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 1
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 that has been acetylated on a Lys residue located within the PDZ domain-binding motif at the C-terminus. Example: UniProtKB:P60484-1, Lys-402, MOD:00064." [PMID:18757404, PRO:PD]
comment: Category=modification.
synonym: "PTEN/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028747 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P60484-3
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform h3 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P60484-3." [PRO:DNx, UniProtKB:P60484]
comment: Category=organism-sequence.
synonym: "hPTEN/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P60484-3
is_a: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P60484-1
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hPTEN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P60484-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028747 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1

[Term]
id: PR:000045843
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN phosphorylated 1 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that has been phosphorylated at the position equivalent to Ser-370 of the amino acid sequence represented by UniProtKB:P60484-1. Example: UniProtKB:P60484-1, Ser-370, MOD:00046." [PMID:19629644, iPTMnet:P60484]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19629644). Status=unreviewed.
synonym: "hPTEN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60484-1, Ser-370, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028804
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 that has been acetylated on Lys residues located within the catalytic core domain. Example: UniProtKB:P60484-1, Lys-125/Lys-128, MOD:00064." [PMID:10619020, PRO:PD]
comment: Category=modification.
synonym: "PTEN/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028747 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028805
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2 in human. Acetylation inhibits PTEN ability to regulate PI3K/Akt pathway and modulates cell cycle progression. UniProtKB:P60484-1, Lys-125/Lys-128, MOD:00064." [PMID:10619020, PRO:PD]
comment: Category=organism-modification. Acetylase=("KAT2B"; PR:000012332).
synonym: "hPTEN/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60484-1, Lys-125/Lys-128, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028804 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine