[Term]
id: PR:000036022
name: traf3:ticam1:ticam2:activated TLR4 complex (human)
def: "A traf3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:16306936, PMID:16306937, Reactome:R-HSA-2201339]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TRAF3:TRIF:TRAM:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201339]
is_a: PR:000028681 ! traf3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035702 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q13114 {cardinality="2"} ! TNF receptor-associated factor 3 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000028681
name: traf3:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), TICAM2, TICAM1 and TRAF3." [PMID:16306937, Reactome:R-HSA-2201339]
comment: Category=complex. Requested by=TLR.
synonym: "TRAF3:TRIF:TRAM:activated TLR4" EXACT [Reactome:R-HSA-2201339]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000028683
name: traf3:ticam1:ticam2:activated TLR4 complex (mouse)
def: "A traf3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of mouse." [PMID:16306937]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TRAF3:TRIF:TRAM:activated TLR4 (mouse)" EXACT []
is_a: PR:000028681 ! traf3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:Q60803 ! TNF receptor-associated factor 3 (mouse)
relationship: has_component PR:Q80UF7 ! TIR domain-containing adapter molecule 1 (mouse)
relationship: has_component PR:Q8BJQ4 ! TIR domain-containing adapter molecule 2 (mouse)