[Term]
id: PR:000027775
name: estrogen receptor isoform 1 phosphorylated 4
def: "An estrogen receptor isoform 1 that has been phosphorylated on a Thr located in the helix 1 of the hormone binding domain. This highly conserved Thr residue is part of a leucine -rich nuclear export signal sequence and phosphorylation at this site blocks ERalpha nuclear export and promotes its transcriptional activation. Example: UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine