[Term]
id: PR:000026125
name: 5-aminolevulinate synthase
def: "A PLP-dependent alpha-oxoamine synthase whose functional form is the first enzyme in the pathway for synthesis of all tetrapyrroles in non-photosynthetic eukaryotes and alpha-proteobacteria. ALAS catalyzes the decarboxylative condensation of glycine and succinyl-CoA, yielding 5-aminolevulinic acid, free coenzyme-A and CO2." [PMID:13598764, PRO:CNA]
comment: Category=family.
synonym: "ALAS" EXACT []
synonym: "5-aminolevulinic acid synthase" EXACT []
xref: PIRSF:PIRSF000444
is_a: PR:000026124 ! PLP-dependent alpha-oxoamine synthase