[Term]
id: PR:000025774
name: MYD88:TIRAP:activated TLR complex
def: "A protein-containing complex that is composed of MyD88, Mal/TIRAP and an activated Toll-like receptor (TLR). Mammalian TLRs function as sensors of infection and induce the activation of innate and adaptive immune responses. Upon recognizing conserved pathogen-associated molecular products, TLRs activate host defence responses through their intracellular signalling domain, the Toll/interleukin-1 receptor (TIR) domain, and the downstream adaptor protein MyD88. Mal/TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs." [PMID:12447441, PMID:12447442, PMID:12888566]
comment: Category=complex.
synonym: "MyD88:Mal:activated TLR complex" EXACT []
synonym: "MyD88:TIRAP complexed with the activated TLR receptor" EXACT []
is_a: GO:0043235 ! receptor complex