[Term]
id: PR:000025498
name: lipopolysaccharide receptor complex 4
def: "A lipopolysaccharide receptor complex that contains the soluble form of CD14, and the lipopolysaccharide (LPS) bound to LY96(MD-2)." [PMID:1281215, PMID:16176659, PMID:7681988]
comment: Category=complex. The soluble form of CD14 is able to transfer the lipopolysaccharide to MD-2 in the tissues where the membrane form is absent.
synonym: "LPSR:4" EXACT PRO-short-label [PRO:DAN]
is_a: GO:0046696 ! lipopolysaccharide receptor complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: has_component PR:000002147 ! CD14 molecule isoform 1 cleaved 2 soluble form
relationship: has_component PR:000003299 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1
relationship: has_component PR:000025492 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1

[Term]
id: PR:000037479
name: lipopolysaccharide receptor complex 4 (human)
def: "A lipopolysaccharide receptor complex 4 whose components are encoded in the genome of human." [PMID:11274165, PRO:VS]
comment: Category=organism-complex.
synonym: "h(LPSR:4)" EXACT PRO-short-label [PRO:DAN]
synonym: "TLR4:MD2:LPS:CD14 (human)" BROAD [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025498 ! lipopolysaccharide receptor complex 4
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035703 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 soluble form (human)