[Term]
id: PR:Q99344
name: NEDD8-activating enzyme E1 catalytic subunit (yeast)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of yeast." [OMA:Q99344, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "UBA3" RELATED Gene-based [UniProtKB:Q99344]
synonym: "yUBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "YPR066W" RELATED Gene-based [UniProtKB:Q99344]
synonym: "YP9499.21" RELATED Gene-based [UniProtKB:Q99344]
synonym: "RUB1-activating enzyme E1 (yeast)" EXACT [UniProtKB:Q99344]
synonym: "ubiquitin-activating enzyme E1 3 (yeast)" EXACT [UniProtKB:Q99344]
synonym: "ubiquitin-like protein-activating enzyme (yeast)" EXACT [UniProtKB:Q99344]
xref: UniProtKB:Q99344
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template SGD:S000006270 ! UBA3 (yeast)

[Term]
id: PR:000041648
name: NEDD8-activating enzyme E1 catalytic subunit isoform 1
def: "A NEDD8-activating enzyme E1 catalytic subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C878-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "UBA3/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit

[Term]
id: PR:Q09765
name: NEDD8-activating enzyme E1 catalytic subunit (Schizosaccharomyces pombe 972h-)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09765, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "uba3" RELATED Gene-based [UniProtKB:Q09765]
synonym: "SPAC24H6.12c" RELATED Gene-based [UniProtKB:Q09765]
synonym: "Spom972h-UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitin-activating enzyme E1 3 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09765]
xref: UniProtKB:Q09765
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template PomBase:SPAC24H6.12c ! uba3 (Schizosaccharomyces pombe)

[Term]
id: PR:Q8C878
name: NEDD8-activating enzyme E1 catalytic subunit (mouse)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of mouse." [OMA:Q8C878, PRO:DNx]
comment: Category=organism-gene.
synonym: "Uba3" RELATED Gene-based [UniProtKB:Q8C878]
synonym: "Ube1c" RELATED Gene-based [UniProtKB:Q8C878]
synonym: "mUBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "NEDD8-activating enzyme E1C (mouse)" EXACT [UniProtKB:Q8C878]
synonym: "ubiquitin-activating enzyme 3 (mouse)" EXACT [UniProtKB:Q8C878]
synonym: "ubiquitin-activating enzyme E1C (mouse)" EXACT [UniProtKB:Q8C878]
synonym: "ubiquitin-like modifier-activating enzyme 3 (mouse)" EXACT [UniProtKB:Q8C878]
xref: UniProtKB:Q8C878
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template MGI:1341217 ! Uba3 (mouse)

[Term]
id: PR:Q7ZVX6
name: NEDD8-activating enzyme E1 catalytic subunit (zebrafish)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of zebrafish." [OMA:Q7ZVX6, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "uba3" RELATED Gene-based [UniProtKB:Q7ZVX6]
synonym: "ube1c" RELATED Gene-based [UniProtKB:Q7ZVX6]
synonym: "z-UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "zgc:55528" RELATED Gene-based [UniProtKB:Q7ZVX6]
synonym: "NEDD8-activating enzyme E1C (zebrafish)" EXACT [UniProtKB:Q7ZVX6]
synonym: "ubiquitin-activating enzyme 3 (zebrafish)" EXACT [UniProtKB:Q7ZVX6]
synonym: "ubiquitin-activating enzyme E1C (zebrafish)" EXACT [UniProtKB:Q7ZVX6]
synonym: "ubiquitin-like modifier-activating enzyme 3 (zebrafish)" EXACT [UniProtKB:Q7ZVX6]
xref: UniProtKB:Q7ZVX6
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template ZFIN:ZDB-GENE-040426-2825 ! uba3 (zebrafish)

[Term]
id: PR:Q8TBC4
name: NEDD8-activating enzyme E1 catalytic subunit (human)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TBC4]
comment: Category=organism-gene.
synonym: "UBA3" RELATED Gene-based [UniProtKB:Q8TBC4]
synonym: "UBE1C" RELATED Gene-based [UniProtKB:Q8TBC4]
synonym: "hUBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "NEDD8-activating enzyme E1C (human)" EXACT [UniProtKB:Q8TBC4]
synonym: "ubiquitin-activating enzyme 3 (human)" EXACT [UniProtKB:Q8TBC4]
synonym: "ubiquitin-activating enzyme E1C (human)" EXACT [UniProtKB:Q8TBC4]
synonym: "ubiquitin-like modifier-activating enzyme 3 (human)" EXACT [UniProtKB:Q8TBC4]
xref: UniProtKB:Q8TBC4
xref: Reactome:R-HSA-947632 "PR:Q8TBC4 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template HGNC:12470 ! UBA3 (human)

[Term]
id: PR:Q99MI7
name: NEDD8-activating enzyme E1 catalytic subunit (rat)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of rat." [OMA:Q99MI7, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Uba3" RELATED Gene-based [UniProtKB:Q99MI7]
synonym: "Ube1c" RELATED Gene-based [UniProtKB:Q99MI7]
synonym: "rUBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "NEDD8-activating enzyme E1C (rat)" EXACT [UniProtKB:Q99MI7]
synonym: "ubiquitin-activating enzyme 3 (rat)" EXACT [UniProtKB:Q99MI7]
synonym: "ubiquitin-activating enzyme E1C (rat)" EXACT [UniProtKB:Q99MI7]
synonym: "ubiquitin-like modifier-activating enzyme 3 (rat)" EXACT [UniProtKB:Q99MI7]
xref: UniProtKB:Q99MI7
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template RGD:621084 ! Uba3 (rat)

[Term]
id: PR:Q9V6U8
name: Nedd8-activating enzyme E1 catalytic subunit (fruit fly)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of fruit fly." [OMA:Q9V6U8, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Uba3" RELATED Gene-based [UniProtKB:Q9V6U8]
synonym: "CG13343" RELATED Gene-based [UniProtKB:Q9V6U8]
synonym: "fly-UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitin-activating enzyme 3 homolog (fruit fly)" EXACT [UniProtKB:Q9V6U8]
xref: UniProtKB:Q9V6U8
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template FlyBase:FBgn0263697 ! Uba3 (fruit fly)

[Term]
id: PR:Q19360
name: NEDD8-activating enzyme E1 catalytic subunit (worm)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of worm." [OMA:Q19360, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "rfl-1" RELATED Gene-based [UniProtKB:Q19360]
synonym: "uba-3" RELATED Gene-based [UniProtKB:Q19360]
synonym: "F11H8.1" RELATED Gene-based [UniProtKB:Q19360]
synonym: "UBA3 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitin-activating enzyme 3 homolog (worm)" EXACT [UniProtKB:Q19360]
synonym: "ectopic membrane ruffles in embryo protein 1 (worm)" EXACT [UniProtKB:Q19360]
xref: UniProtKB:Q19360
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template WormBase:WBGene00004341 ! rfl-1 (worm)

[Term]
id: PR:O65041
name: NEDD8-activating enzyme E1 catalytic subunit (Arabidopsis thaliana)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of Arabidopsis thaliana." [OMA:O65041, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "ECR1" RELATED Gene-based [UniProtKB:O65041]
synonym: "At-UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "T24G5_80" RELATED Gene-based [UniProtKB:O65041]
synonym: "At5g19180" RELATED Gene-based [UniProtKB:O65041]
synonym: "RUB-activating enzyme (Arabidopsis thaliana)" EXACT [UniProtKB:O65041]
synonym: "ubiquitin-activating enzyme E1-like protein (Arabidopsis thaliana)" EXACT [UniProtKB:O65041]
xref: UniProtKB:O65041
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template Araport:AT5G19180 ! ECR1 (Arabidopsis thaliana)

[Term]
id: PR:Q8C878-2
name: NEDD8-activating enzyme E1 catalytic subunit isoform m2 (mouse)
def: "A NEDD8-activating enzyme E1 catalytic subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C878-2." [PRO:DNx, UniProtKB:Q8C878]
comment: Category=organism-sequence.
synonym: "mUBA3/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8C878-2
is_a: PR:Q8C878 ! NEDD8-activating enzyme E1 catalytic subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8C878-1
name: NEDD8-activating enzyme E1 catalytic subunit isoform 1 (mouse)
def: "A NEDD8-activating enzyme E1 catalytic subunit isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mUBA3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8C878-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000041648 ! NEDD8-activating enzyme E1 catalytic subunit isoform 1

[Term]
id: PR:000016952
name: NEDD8-activating enzyme E1 catalytic subunit
def: "A protein that is a translation product of the human UBA3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "UBE1C" RELATED Gene-based []
synonym: "NEDD8-activating enzyme E1C" EXACT []
synonym: "ubiquitin-activating enzyme 3" EXACT []
synonym: "ubiquitin-activating enzyme E1C" EXACT []
synonym: "ubiquitin-like modifier-activating enzyme 3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8TBC4-1
name: NEDD8-activating enzyme E1 catalytic subunit isoform h1 (human)
def: "A NEDD8-activating enzyme E1 catalytic subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TBC4-1." [PRO:DNx, UniProtKB:Q8TBC4]
comment: Category=organism-sequence.
synonym: "hUBA3/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TBC4-1
is_a: PR:Q8TBC4 ! NEDD8-activating enzyme E1 catalytic subunit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8TBC4-2
name: NEDD8-activating enzyme E1 catalytic subunit isoform h2 (human)
def: "A NEDD8-activating enzyme E1 catalytic subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TBC4-2." [PRO:DNx, UniProtKB:Q8TBC4]
comment: Category=organism-sequence.
synonym: "hUBA3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TBC4-2
is_a: PR:Q8TBC4 ! NEDD8-activating enzyme E1 catalytic subunit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99MI7-1
name: NEDD8-activating enzyme E1 catalytic subunit isoform 1 (rat)
def: "A NEDD8-activating enzyme E1 catalytic subunit isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rUBA3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99MI7-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000041648 ! NEDD8-activating enzyme E1 catalytic subunit isoform 1

[Term]
id: PR:Q54QG9
name: NEDD8-activating enzyme E1 catalytic subunit (Dictyostelium discoideum)
def: "A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54QG9, PANTHER:PTHR10953:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "uba3" RELATED Gene-based [UniProtKB:Q54QG9]
synonym: "ube1c" RELATED Gene-based [UniProtKB:Q54QG9]
synonym: "Dicty-UBA3" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0283891" RELATED Gene-based [UniProtKB:Q54QG9]
synonym: "NEDD8-activating enzyme E1C (Dictyostelium discoideum)" EXACT [UniProtKB:Q54QG9]
synonym: "ubiquitin-activating enzyme 3 (Dictyostelium discoideum)" EXACT [UniProtKB:Q54QG9]
synonym: "ubiquitin-activating enzyme E1C (Dictyostelium discoideum)" EXACT [UniProtKB:Q54QG9]
synonym: "ubiquitin-like modifier-activating enzyme 3 (Dictyostelium discoideum)" EXACT [UniProtKB:Q54QG9]
xref: UniProtKB:Q54QG9
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000016952 ! NEDD8-activating enzyme E1 catalytic subunit
relationship: has_gene_template dictyBase:DDB_G0283891 ! ube1c (Dictyostelium discoideum)