[Term]
id: PR:P10639-1
name: thioredoxin isoform 1 (mouse)
def: "A thioredoxin isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mTXN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10639-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038812 ! thioredoxin isoform 1

[Term]
id: PR:P10599
name: thioredoxin (human)
def: "A thioredoxin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10599]
comment: Category=organism-gene.
synonym: "TRX" RELATED Gene-based [UniProtKB:P10599]
synonym: "TXN" RELATED Gene-based [UniProtKB:P10599]
synonym: "TRDX" RELATED Gene-based [UniProtKB:P10599]
synonym: "TRX1" RELATED Gene-based [UniProtKB:P10599]
synonym: "hTXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Hom s Trx" EXACT [UniProtKB:P10599]
synonym: "ADF (human)" BROAD [UniProtKB:P10599]
synonym: "SASP (human)" EXACT [UniProtKB:P10599]
synonym: "ATL-derived factor (human)" EXACT [UniProtKB:P10599]
synonym: "surface-associated sulphydryl protein (human)" EXACT [UniProtKB:P10599]
xref: UniProtKB:P10599
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template HGNC:12435 ! TXN (human)

[Term]
id: PR:P10599-2
name: thioredoxin isoform h2 (human)
def: "A thioredoxin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10599-2." [PRO:DNx, UniProtKB:P10599]
comment: Category=organism-sequence.
synonym: "hTXN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10599-2
is_a: PR:P10599 ! thioredoxin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P14949
name: thioredoxin (Bacillus subtilis subsp. subtilis str. 168)
def: "A thioredoxin that is encoded in the genome of Bacillus subtilis subsp. subtilis str. 168." [OMA:P14949, PRO:DNx]
comment: Category=organism-gene. Note: Additional NCBIGenes (GeneIDs) listed in the UniProtKB entry have been reviewed and removed by PRO:DNx.
synonym: "trx" RELATED Gene-based [UniProtKB:P14949]
synonym: "trxA" RELATED Gene-based [UniProtKB:P14949]
synonym: "BSU28500" RELATED Gene-based [UniProtKB:P14949]
synonym: "TXN (BACSU)" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx (Bacillus subtilis subsp. subtilis str. 168)" EXACT [UniProtKB:P14949]
xref: UniProtKB:P14949
intersection_of: only_in_taxon NCBITaxon:224308 ! Bacillus subtilis subsp. subtilis str. 168
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template NCBIGene:938187 ! trxA (Bacillus subtilis subsp. subtilis str. 168)

[Term]
id: PR:P10599-1
name: thioredoxin isoform 1 (human)
def: "A thioredoxin isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hTXN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10599-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038812 ! thioredoxin isoform 1

[Term]
id: PR:P08629-1
name: thioredoxin isoform 1 (chicken)
def: "A thioredoxin isoform 1 that is encoded in the genome of chicken." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "chick-TXN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08629-1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000038812 ! thioredoxin isoform 1

[Term]
id: PR:P11232
name: thioredoxin (rat)
def: "A thioredoxin that is encoded in the genome of rat." [OMA:P11232, PRO:DNx]
comment: Category=organism-gene.
synonym: "Txn" RELATED Gene-based [UniProtKB:P11232]
synonym: "Txn1" RELATED Gene-based [UniProtKB:P11232]
synonym: "rTXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx (rat)" EXACT [UniProtKB:P11232]
xref: UniProtKB:P11232
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template RGD:621157 ! Txn1 (rat)

[Term]
id: PR:P10639
name: thioredoxin (mouse)
def: "A thioredoxin that is encoded in the genome of mouse." [OMA:P10639, PRO:DNx]
comment: Category=organism-gene.
synonym: "Txn" RELATED Gene-based [UniProtKB:P10639]
synonym: "Txn1" RELATED Gene-based [UniProtKB:P10639]
synonym: "mTXN" EXACT PRO-short-label [PRO:DNx]
synonym: "ADF (mouse)" RELATED [UniProtKB:P10639]
synonym: "Trx (mouse)" EXACT [UniProtKB:P10639]
synonym: "ATL-derived factor (mouse)" EXACT [UniProtKB:P10639]
xref: UniProtKB:P10639
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template MGI:98874 ! Txn1 (mouse)

[Term]
id: PR:000021752
name: thioredoxin, initiator methionine removed form
def: "A thioredoxin that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "TXN/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000016853 ! thioredoxin
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P11232-1
name: thioredoxin isoform 1 (rat)
def: "A thioredoxin isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rTXN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11232-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038812 ! thioredoxin isoform 1

[Term]
id: PR:000049566
name: thioredoxin, initiator methionine removed form (human)
def: "A thioredoxin (human) that has had the initiator methionine removed. UniProtKB:P10599, 2-105." [PRO:DNx, Reactome:R-HSA-66000]
comment: Category=organism-modification.
synonym: "hTXN/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000120005" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10599, 2-105" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-66000 "PR:000049566 located_in GO:0005829"
xref: Reactome:R-HSA-9617732 "PR:000049566 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P10599 ! thioredoxin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028949
name: thioredoxin-1 oxidized form (Schizosaccharomyces pombe)
def: "A thioredoxin oxidized form in Schizosaccharomyces pombe. The disulfide bond involves residues corresponding to Cys-30 and Cys-33 of the amino acid sequence represented by UniProtKB:O14463." [PMID:22245228, PRO:CNA]
comment: Category=organism-modification. Requested by=PomBase.
synonym: "Spom-TXN/Ox+" EXACT PRO-short-label [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000028948 ! thioredoxin oxidized form

[Term]
id: PR:000028948
name: thioredoxin oxidized form
def: "A thioredoxin that the Cys residues involved in dithiol-disulfide activity (CxxC motif) are forming disulfide bond." [PMID:22245228, PRO:CNA]
comment: Category=modification.
synonym: "TXN/Ox+" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx1-S2" RELATED []
is_a: PR:000016853 ! thioredoxin

[Term]
id: PR:000028947
name: thioredoxin-1 reduced form (Schizosaccharomyces pombe)
def: "A thioredoxin reduced form in Schizosaccharomyces pombe. The reduced Cys are on residues corresponding to Cys-30 and Cys-33 of the amino acid sequence represented by UniProtKB:O14463." [PMID:22245228, PRO:CNA]
comment: Category=organism-modification. Requested by=PomBase.
synonym: "Spom-TXN/Red+" EXACT PRO-short-label [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000028946 ! thioredoxin reduced form

[Term]
id: PR:000028946
name: thioredoxin reduced form
def: "A thioredoxin that the Cys residues involved in dithiol-disulfide activity (CxxC motif) are in the reduced state." [PMID:22245228, PRO:CNA]
comment: Category=modification.
synonym: "TXN/Red+" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx1-(SH)2" RELATED []
is_a: PR:000016853 ! thioredoxin

[Term]
id: PR:000038812
name: thioredoxin isoform 1
def: "A thioredoxin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10599-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "TXN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016853 ! thioredoxin

[Term]
id: PR:000016853
name: thioredoxin
def: "A protein that is a translation product of the human TXN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ADF" RELATED []
synonym: "TRX" RELATED Gene-based []
synonym: "TXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx" EXACT []
synonym: "SASP" EXACT []
synonym: "TRDX" RELATED Gene-based []
synonym: "TRX1" RELATED Gene-based []
synonym: "Txn1" RELATED Gene-based []
synonym: "ATL-derived factor" EXACT []
synonym: "surface-associated sulphydryl protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P08629
name: thioredoxin (chicken)
def: "A thioredoxin that is encoded in the genome of chicken." [OMA:P08629, PANTHER:PTHR10438:SF18, PRO:DNx]
comment: Category=organism-gene.
synonym: "TXN" RELATED Gene-based [UniProtKB:P08629]
synonym: "chick-TXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx (chicken)" EXACT [UniProtKB:P08629]
xref: UniProtKB:P08629
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template NCBIGene:396437 ! TXN (chicken)

[Term]
id: PR:000045665
name: thioredoxin phosphorylated 1 (human)
def: "A thioredoxin (human) that has been phosphorylated at the position equivalent to Thr-100 of the amino acid sequence represented by UniProtKB:P10599-1. Example: UniProtKB:P10599-1, Thr-100, MOD:00047." [PMID:20619274, iPTMnet:P10599]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20619274). Status=unreviewed.
synonym: "hTXN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10599-1, Thr-100, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P10599 ! thioredoxin (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens