[Term]
id: PR:P49816-4
name: tuberin isoform r4 (rat)
def: "A tuberin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49816-4." [PRO:DNx, UniProtKB:P49816]
comment: Category=organism-sequence.
synonym: "rTSC2/iso:r4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49816-4
is_a: PR:P49816 ! tuberin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P49816-2
name: tuberin isoform r2 (rat)
def: "A tuberin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49816-2." [PRO:DNx, UniProtKB:P49816]
comment: Category=organism-sequence.
synonym: "rTSC2/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49816-2
is_a: PR:P49816 ! tuberin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P49816-3
name: tuberin isoform r3 (rat)
def: "A tuberin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49816-3." [PRO:DNx, UniProtKB:P49816]
comment: Category=organism-sequence.
synonym: "rTSC2/iso:r3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49816-3
is_a: PR:P49816 ! tuberin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P49816-1
name: tuberin isoform r1 (rat)
def: "A tuberin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49816-1." [PRO:DNx, UniProtKB:P49816]
comment: Category=organism-sequence.
synonym: "rTSC2/iso:r1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49816-1
is_a: PR:P49816 ! tuberin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049555
name: tuberin phosphorylated 3 (human)
def: "A tuberin (human) that has been post-translationally modified to include phosphoserine at position 939, and phosphothreonine at position 1462 of the amino acid sequence represented by UniProtKB:P49815. UniProtKB:P49815, Ser-939, MOD:00046|Thr-1462, MOD:00047." [PRO:DNx, Reactome:R-HSA-199484]
comment: Category=organism-modification.
synonym: "hTSC2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49815, Ser-939, MOD:00046|Thr-1462, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-199484 "PR:000049555 located_in GO:0005829"
is_a: PR:P49815 ! tuberin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049554
name: tuberin phosphorylated 2 (human)
def: "A tuberin (human) that has been post-translationally modified to include phosphoserine at position 1387 of the amino acid sequence represented by UniProtKB:P49815. UniProtKB:P49815, Ser-1387, MOD:00046." [PRO:DNx, Reactome:R-HSA-3132769]
comment: Category=organism-modification.
synonym: "hTSC2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49815, Ser-1387, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3132769 "PR:000049554 located_in GO:0005829"
is_a: PR:P49815 ! tuberin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049556
name: tuberin phosphorylated 4 (human)
def: "A tuberin (human) that has been post-translationally modified to include phosphoserine at positions 939 and 1130, and phosphothreonine at position 1462 of the amino acid sequence represented by UniProtKB:P49815. UniProtKB:P49815, Ser-939/Ser-1130, MOD:00046|Thr-1462, MOD:00047." [PRO:DNx, Reactome:R-HSA-165164]
comment: Category=organism-modification.
synonym: "hTSC2/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49815, Ser-939/Ser-1130, MOD:00046|Thr-1462, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-165164 "PR:000049556 located_in GO:0005829"
is_a: PR:P49815 ! tuberin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026792
name: tuberin isoform 1
def: "A tuberin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "TSC2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016709 ! tuberin

[Term]
id: PR:Q9UUG9
name: tuberous sclerosis 2 protein homolog (Schizosaccharomyces pombe 972h-)
def: "A tuberin that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PANTHER:PTHR10063:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "tsc2" RELATED Gene-based [UniProtKB:Q9UUG9]
synonym: "SPAC630.13c" RELATED Gene-based [UniProtKB:Q9UUG9]
synonym: "Spom972h-TSC2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UUG9
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000016709 ! tuberin
relationship: has_gene_template PomBase:SPAC630.13c ! tsc2 (Schizosaccharomyces pombe)

[Term]
id: PR:000016709
name: tuberin
def: "A protein that is a translation product of the human TSC2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TSC2" EXACT PRO-short-label [PRO:DNx]
synonym: "TSC4" RELATED Gene-based []
synonym: "tuberous sclerosis 2 protein" EXACT []
synonym: "tuberous sclerosis 2 protein homolog" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q61037-1
name: tuberin isoform G (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-1." [PMID:777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:G" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-1
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-2
name: tuberin isoform A (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-2." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-2
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-3
name: tuberin isoform B (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-3." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-3
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-4
name: tuberin isoform C (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-4." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-4
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-5
name: tuberin isoform D (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-5." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:D" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-5
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-6
name: tuberin isoform E (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-6." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:E" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-6
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q61037-7
name: tuberin isoform F (mouse)
def: "A tuberin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61037-7." [PMID:8777431, PRO:HJD, UniProtKB:Q61037]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:F" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61037-7
is_a: PR:Q61037 ! tuberin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P49815
name: tuberin (human)
def: "A tuberin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-gene.
synonym: "TSC2" RELATED Gene-based [UniProtKB:P49815]
synonym: "TSC4" RELATED Gene-based [UniProtKB:P49815]
synonym: "hTSC2" EXACT PRO-short-label [PRO:DNx]
synonym: "tuberous sclerosis 2 protein (human)" EXACT [UniProtKB:P49815]
xref: Reactome:R-HSA-2980548 "PR:P49815 located_in GO:0005829"
xref: UniProtKB:P49815
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016709 ! tuberin
relationship: has_gene_template HGNC:12363 ! TSC2 (human)

[Term]
id: PR:P49816
name: tuberin (rat)
def: "A tuberin that is encoded in the genome of rat." [OMA:P49816, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tsc2" RELATED Gene-based [UniProtKB:P49816]
synonym: "rTSC2" EXACT PRO-short-label [PRO:DNx]
synonym: "tuberous sclerosis 2 protein homolog (rat)" EXACT [UniProtKB:P49816]
xref: UniProtKB:P49816
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016709 ! tuberin
relationship: has_gene_template RGD:3908 ! Tsc2 (rat)

[Term]
id: PR:P49815-8
name: tuberin isoform h8 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-8." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h8" EXACT PRO-short-label [PRO:DNx]
synonym: "tuberin isoform H (human)" EXACT [UniProtKB:P49815]
synonym: "tuberin isoform I (human)" EXACT [UniProtKB:P49815]
xref: UniProtKB:P49815-8
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-5
name: tuberin isoform h5 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-5." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-5
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-4
name: tuberin isoform h4 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-4." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-4
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-7
name: tuberin isoform h7 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-7." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-7
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-6
name: tuberin isoform h6 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-6." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-6
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-1
name: tuberin isoform 1 (human)
def: "A tuberin isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026792 ! tuberin isoform 1

[Term]
id: PR:P49815-3
name: tuberin isoform h3 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-3." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-3
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49815-2
name: tuberin isoform h2 (human)
def: "A tuberin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49815-2." [PRO:DNx, UniProtKB:P49815]
comment: Category=organism-sequence.
synonym: "hTSC2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49815-2
is_a: PR:P49815 ! tuberin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q61037
name: tuberin (mouse)
def: "A tuberin that is encoded in the genome of mouse." [OMA:Q61037, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tsc2" RELATED Gene-based [UniProtKB:Q61037]
synonym: "mTSC2" EXACT PRO-short-label [PRO:DNx]
synonym: "tuberous sclerosis 2 protein homolog (mouse)" EXACT [UniProtKB:Q61037]
xref: UniProtKB:Q61037
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016709 ! tuberin
relationship: has_gene_template MGI:102548 ! Tsc2 (mouse)

[Term]
id: PR:Q3UHB2
name: tuberin isoform 1 (mouse)
def: "A tuberin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTSC2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q3UHB2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026792 ! tuberin isoform 1

[Term]
id: PR:000045806
name: tuberin phosphorylated 1 (human)
def: "A tuberin (human) that has been phosphorylated at the position equivalent to Tyr-1571 of the amino acid sequence represented by UniProtKB:P49815-1. Example: UniProtKB:P49815-1, Tyr-1571, MOD:00048." [PMID:11290735, iPTMnet:P49815]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11290735). Status=unreviewed.
synonym: "hTSC2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49815-1, Tyr-1571, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49815 ! tuberin (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens