[Term]
id: PR:Q09778
name: tuberous sclerosis 1 protein homolog (Schizosaccharomyces pombe 972h-)
def: "A hamartin that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PANTHER:PTHR15154:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "tsc1" RELATED Gene-based [UniProtKB:Q09778]
synonym: "SPAC22F3.13" RELATED Gene-based [UniProtKB:Q09778]
synonym: "Spom972h-TSC1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09778
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000016708 ! hamartin
relationship: has_gene_template PomBase:SPAC22F3.13 ! tsc1 (Schizosaccharomyces pombe)

[Term]
id: PR:000046009
name: hamartin phosphorylated 1 (human)
def: "A hamartin (human) that has been phosphorylated at the position equivalent to Ser-511 of the amino acid sequence represented by UniProtKB:Q92574-1. Example: UniProtKB:Q92574-1, Ser-511, MOD:00046." [PMID:24135021, iPTMnet:Q92574]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:24135021). Status=unreviewed.
synonym: "hTSC1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92574-1, Ser-511, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q92574 ! hamartin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92574-1
name: hamartin isoform h1 (human)
def: "A hamartin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92574-1." [PRO:DNx, UniProtKB:Q92574]
comment: Category=organism-sequence.
synonym: "hTSC1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92574-1
is_a: PR:Q92574 ! hamartin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Z136
name: hamartin (rat)
def: "A hamartin that is encoded in the genome of rat." [OMA:Q9Z136, PANTHER:PTHR15154:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tsc1" RELATED Gene-based [UniProtKB:Q9Z136]
synonym: "rTSC1" EXACT PRO-short-label [PRO:DNx]
synonym: "tuberous sclerosis 1 protein homolog (rat)" EXACT [UniProtKB:Q9Z136]
xref: UniProtKB:Q9Z136
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016708 ! hamartin
relationship: has_gene_template RGD:620124 ! Tsc1 (rat)

[Term]
id: PR:Q9EP53-4
name: hamartin isoform 4 (mouse)
def: "A hamartin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EP53-4." [PMID:15489334, PRO:HJD, UniProtKB:Q9EP53]
comment: Category=organism-sequence.
synonym: "mTSC1/iso:4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EP53-4
is_a: PR:Q9EP53 ! hamartin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000030168
name: hamartin phosphorylated 1
def: "A hamartin that has been phosphorylated at the position equivalent to Ser-394 of the amino acid sequence represented by UniProtKB:Q9EP53. Example: UniProtKB:Q9EP53, Ser-394, MOD:00046." [PMID:17114649, PRO:HJD]
comment: Category=modification. Note: Large-scale experiment.
synonym: "TSC1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016708 ! hamartin
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000030169
name: hamartin phosphorylated 1 (mouse)
def: "A hamartin phosphorylated 1 in mouse. UniProtKB:Q9EP53, Ser-394, MOD:00046." [PMID:17114649, PRO:HJD]
comment: Category=organism-modification. Note: Large-scale experiment.
synonym: "mTSC1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9EP53, Ser-394, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000030168 ! hamartin phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q92574-2
name: hamartin isoform h2 (human)
def: "A hamartin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92574-2." [PRO:DNx, UniProtKB:Q92574]
comment: Category=organism-sequence.
synonym: "hTSC1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92574-2
is_a: PR:Q92574 ! hamartin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9EP53
name: hamartin (mouse)
def: "A hamartin that is encoded in the genome of mouse." [OMA:Q9EP53, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tsc1" RELATED Gene-based [UniProtKB:Q9EP53]
synonym: "mTSC1" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa0243" RELATED Gene-based [UniProtKB:Q9EP53]
synonym: "tuberous sclerosis 1 protein homolog (mouse)" EXACT [UniProtKB:Q9EP53]
xref: UniProtKB:Q9EP53
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016708 ! hamartin
relationship: has_gene_template MGI:1929183 ! Tsc1 (mouse)

[Term]
id: PR:Q92574
name: hamartin (human)
def: "A hamartin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92574]
comment: Category=organism-gene.
synonym: "TSC" RELATED Gene-based [UniProtKB:Q92574]
synonym: "TSC1" RELATED Gene-based [UniProtKB:Q92574]
synonym: "hTSC1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0243" RELATED Gene-based [UniProtKB:Q92574]
synonym: "tuberous sclerosis 1 protein (human)" EXACT [UniProtKB:Q92574]
xref: UniProtKB:Q92574
xref: Reactome:R-HSA-165169 "PR:Q92574 located_in GO:0005886"
xref: Reactome:R-HSA-5672338 "PR:Q92574 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016708 ! hamartin
relationship: has_gene_template HGNC:12362 ! TSC1 (human)

[Term]
id: PR:Q9EP53-3
name: hamartin isoform 3 (mouse)
def: "A hamartin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EP53-3." [PMID:16141072, PRO:HJD, UniProtKB:Q9EP53]
comment: Category=organism-sequence.
synonym: "mTSC1/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EP53-3
is_a: PR:Q9EP53 ! hamartin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9EP53-2
name: hamartin isoform 2 (mouse)
def: "A hamartin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EP53-2." [PMID:11130985, PRO:HJD, UniProtKB:Q9EP53]
comment: Category=organism-sequence.
synonym: "mTSC1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EP53-2
is_a: PR:Q9EP53 ! hamartin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000016708
name: hamartin
def: "A protein that is a translation product of the human TSC1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TSC" RELATED Gene-based []
synonym: "TSC1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0243" RELATED Gene-based []
synonym: "tuberous sclerosis 1 protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9EP53-1
name: hamartin isoform 1 (mouse)
def: "A hamartin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EP53-1." [PMID:11130985, PRO:HJD, UniProtKB:Q9EP53]
comment: Category=organism-sequence.
synonym: "mTSC1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EP53-1
is_a: PR:Q9EP53 ! hamartin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus