[Term]
id: PR:Q64511
name: DNA topoisomerase 2-beta (mouse)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of mouse." [OMA:Q64511, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top2b" RELATED Gene-based [UniProtKB:Q64511]
synonym: "mTOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, beta isozyme (mouse)" EXACT [UniProtKB:Q64511]
xref: UniProtKB:Q64511
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template MGI:98791 ! Top2b (mouse)

[Term]
id: PR:Q55BP5
name: probable DNA topoisomerase 2 (Dictyostelium discoideum)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]
comment: Category=organism-gene.
synonym: "top2" RELATED Gene-based [UniProtKB:Q55BP5]
synonym: "topB" RELATED Gene-based [UniProtKB:Q55BP5]
synonym: "Dicty-TOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0270418" RELATED Gene-based [UniProtKB:Q55BP5]
synonym: "DNA topoisomerase II (Dictyostelium discoideum)" EXACT [UniProtKB:Q55BP5]
xref: UniProtKB:Q55BP5
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template dictyBase:DDB_G0270418 ! top2 (Dictyostelium discoideum)

[Term]
id: PR:Q02880
name: DNA topoisomerase 2-beta (human)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q02880]
comment: Category=organism-gene.
synonym: "TOP2B" RELATED Gene-based [UniProtKB:Q02880]
synonym: "hTOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, beta isozyme (human)" EXACT [UniProtKB:Q02880]
xref: Reactome:R-HSA-4641359 "PR:Q02880 located_in GO:0005654"
xref: UniProtKB:Q02880
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template HGNC:11990 ! TOP2B (human)

[Term]
id: PR:P15348
name: DNA topoisomerase 2 (fruit fly)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of fruit fly." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Top2" RELATED Gene-based [UniProtKB:P15348]
synonym: "CG10223" RELATED Gene-based [UniProtKB:P15348]
synonym: "fly-TOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II (fruit fly)" EXACT [UniProtKB:P15348]
xref: UniProtKB:P15348
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template FlyBase:FBgn0003732 ! Top2 (fruit fly)

[Term]
id: PR:P30182-1
name: DNA topoisomerase 2 isoform 1 (Arabidopsis thaliana)
def: "A DNA topoisomerase 2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30182-1." [PRO:DNx, UniProtKB:P30182]
comment: Category=organism-sequence.
synonym: "At-TOP2B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P30182-1
is_a: PR:P30182 ! DNA topoisomerase 2 (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:Q23670
name: DNA topoisomerase 2 top-2 (worm)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "top-2" RELATED Gene-based [UniProtKB:Q23670]
synonym: "K12D12.1" RELATED Gene-based [UniProtKB:Q23670]
synonym: "TOP2B (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II (worm)" EXACT [UniProtKB:Q23670]
xref: UniProtKB:Q23670
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template WormBase:WBGene00010785 ! top-2 (worm)

[Term]
id: PR:000016545
name: DNA topoisomerase 2-beta
def: "A protein that is a translation product of the human TOP2B gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, beta isozyme" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P30182
name: DNA topoisomerase 2 (Arabidopsis thaliana)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]
comment: Category=organism-gene.
synonym: "TOP2" RELATED Gene-based [UniProtKB:P30182]
synonym: "At-TOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "F14O13.7" RELATED Gene-based [UniProtKB:P30182]
synonym: "At3g23890" RELATED Gene-based [UniProtKB:P30182]
synonym: "DNA topoisomerase II (Arabidopsis thaliana)" EXACT [UniProtKB:P30182]
xref: UniProtKB:P30182
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template Araport:AT3G23890 ! TOP2 (Arabidopsis thaliana)

[Term]
id: PR:O42131
name: DNA topoisomerase 2-beta (chicken)
def: "A DNA topoisomerase 2-beta that is encoded in the genome of chicken." [OMA:O42131, PANTHER:PTHR10169:SF18, PRO:DNx]
comment: Category=organism-gene.
synonym: "TOP2B" RELATED Gene-based [UniProtKB:O42131]
synonym: "chick-TOP2B" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase II, beta isozyme (chicken)" EXACT [UniProtKB:O42131]
xref: UniProtKB:O42131
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000016545 ! DNA topoisomerase 2-beta
relationship: has_gene_template NCBIGene:395966 ! TOP2B (chicken)

[Term]
id: PR:Q02880-1
name: DNA topoisomerase 2-beta isoform hBeta-2 (human)
def: "A DNA topoisomerase 2-beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02880-1." [PRO:DNx, UniProtKB:Q02880]
comment: Category=organism-sequence.
synonym: "hTOP2B/iso:hBeta-2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q02880-1
is_a: PR:Q02880 ! DNA topoisomerase 2-beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049510
name: DNA topoisomerase 2-beta sumoylated form (human)
def: "A DNA topoisomerase 2-beta (human) that includes at least one sumoylated lysine. UniProtKB:Q02880, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641297]
comment: Category=organism-modification.
synonym: "hTOP2B/SumoLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q02880, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641297 "PR:000049510 located_in GO:0005654"
intersection_of: has_part MOD:01149 ! sumoylated lysine
intersection_of: PR:Q02880 ! DNA topoisomerase 2-beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q02880-2
name: DNA topoisomerase 2-beta isoform hBeta-1 (human)
def: "A DNA topoisomerase 2-beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02880-2." [PRO:DNx, UniProtKB:Q02880]
comment: Category=organism-sequence.
synonym: "hTOP2B/iso:hBeta-1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q02880-2
is_a: PR:Q02880 ! DNA topoisomerase 2-beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens