[Term]
id: PR:Q09474
name: tryptophan 2,3-dioxygenase (worm)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of worm." [OMA:Q09474, PANTHER:PTHR10138:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "tdo-2" RELATED Gene-based [UniProtKB:Q09474]
synonym: "C28H8.11" RELATED Gene-based [UniProtKB:Q09474]
synonym: "TO (worm)" EXACT [UniProtKB:Q09474]
synonym: "TDO (worm)" EXACT [UniProtKB:Q09474]
synonym: "TDO2 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPO (worm)" EXACT [UniProtKB:Q09474]
synonym: "tryptophanase (worm)" EXACT [UniProtKB:Q09474]
synonym: "tryptophan oxygenase (worm)" EXACT [UniProtKB:Q09474]
synonym: "tryptophan pyrrolase (worm)" EXACT [UniProtKB:Q09474]
synonym: "tryptamin 2,3-dioxygenase (worm)" EXACT [UniProtKB:Q09474]
xref: UniProtKB:Q09474
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template WormBase:WBGene00016201 ! tdo-2 (worm)

[Term]
id: PR:P48775-1
name: tryptophan 2,3-dioxygenase isoform 1 (human)
def: "A tryptophan 2,3-dioxygenase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hTDO2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48775-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039566 ! tryptophan 2,3-dioxygenase isoform 1

[Term]
id: PR:Q09474-3
name: tryptophan 2,3-dioxygenase isoform c (worm)
def: "A tryptophan 2,3-dioxygenase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q09474-3." [PRO:DNx, UniProtKB:Q09474]
comment: Category=organism-sequence.
synonym: "TDO2/iso:c (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09474-3
is_a: PR:Q09474 ! tryptophan 2,3-dioxygenase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P21643
name: tryptophan 2,3-dioxygenase (rat)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of rat." [OMA:P21643, PANTHER:PTHR10138:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tdo" RELATED Gene-based [UniProtKB:P21643]
synonym: "Tdo2" RELATED Gene-based [UniProtKB:P21643]
synonym: "rTDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TO (rat)" EXACT [UniProtKB:P21643]
synonym: "TDO (rat)" EXACT [UniProtKB:P21643]
synonym: "TRPO (rat)" EXACT [UniProtKB:P21643]
synonym: "tryptophanase (rat)" EXACT [UniProtKB:P21643]
synonym: "tryptophan oxygenase (rat)" EXACT [UniProtKB:P21643]
synonym: "tryptophan pyrrolase (rat)" EXACT [UniProtKB:P21643]
synonym: "tryptamin 2,3-dioxygenase (rat)" EXACT [UniProtKB:P21643]
xref: UniProtKB:P21643
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template RGD:68370 ! Tdo2 (rat)

[Term]
id: PR:Q55DB4
name: tryptophan 2,3-dioxygenase (Dictyostelium discoideum)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of Dictyostelium discoideum." [OMA:Q55DB4, PANTHER:PTHR10138:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "tdo" RELATED Gene-based [UniProtKB:Q55DB4]
synonym: "Dicty-TDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0269714" RELATED Gene-based [UniProtKB:Q55DB4]
synonym: "TO (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "TDO (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "TRPO (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "tryptophanase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "tryptophan oxygenase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "tryptophan pyrrolase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
synonym: "tryptamin 2,3-dioxygenase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55DB4]
xref: UniProtKB:Q55DB4
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template dictyBase:DDB_G0269714 ! tdo (Dictyostelium discoideum)

[Term]
id: PR:P48776-1
name: tryptophan 2,3-dioxygenase isoform 1 (mouse)
def: "A tryptophan 2,3-dioxygenase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mTDO2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48776-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039566 ! tryptophan 2,3-dioxygenase isoform 1

[Term]
id: PR:P20351
name: tryptophan 2,3-dioxygenase (fruit fly)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of fruit fly." [OMA:P20351, PANTHER:PTHR10138:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "v" RELATED Gene-based [UniProtKB:P20351]
synonym: "CG5163" RELATED Gene-based [UniProtKB:P20351]
synonym: "fly-TDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TO (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "TDO (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "TRPO (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "tryptophanase (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "protein vermilion (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "tryptophan oxygenase (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "tryptophan pyrrolase (fruit fly)" EXACT [UniProtKB:P20351]
synonym: "tryptamin 2,3-dioxygenase (fruit fly)" EXACT [UniProtKB:P20351]
xref: UniProtKB:P20351
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template FlyBase:FBgn0003965 ! v (fruit fly)

[Term]
id: PR:000039566
name: tryptophan 2,3-dioxygenase isoform 1
def: "A tryptophan 2,3-dioxygenase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48775-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "TDO2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016214 ! tryptophan 2,3-dioxygenase

[Term]
id: PR:000016214
name: tryptophan 2,3-dioxygenase
def: "A protein that is a translation product of the human TDO2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TO" EXACT []
synonym: "TDO" RELATED Gene-based []
synonym: "TDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPO" EXACT []
synonym: "tryptophanase" BROAD [PRO:DNx]
synonym: "tryptophan oxygenase" EXACT []
synonym: "tryptophan pyrrolase" EXACT []
synonym: "tryptamin 2,3-dioxygenase" EXACT []
xref: IUPHARobj:2887
is_a: PR:000000001 ! protein

[Term]
id: PR:P48776
name: tryptophan 2,3-dioxygenase (mouse)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of mouse." [OMA:P48776, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tdo" RELATED Gene-based [UniProtKB:P48776]
synonym: "Tdo2" RELATED Gene-based [UniProtKB:P48776]
synonym: "mTDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TO (mouse)" EXACT [UniProtKB:P48776]
synonym: "TDO (mouse)" EXACT [UniProtKB:P48776]
synonym: "TRPO (mouse)" EXACT [UniProtKB:P48776]
synonym: "tryptophanase (mouse)" EXACT [UniProtKB:P48776]
synonym: "tryptophan oxygenase (mouse)" EXACT [UniProtKB:P48776]
synonym: "tryptophan pyrrolase (mouse)" EXACT [UniProtKB:P48776]
synonym: "tryptamin 2,3-dioxygenase (mouse)" EXACT [UniProtKB:P48776]
xref: UniProtKB:P48776
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template MGI:1928486 ! Tdo2 (mouse)

[Term]
id: PR:Q09474-1
name: tryptophan 2,3-dioxygenase isoform a (worm)
def: "A tryptophan 2,3-dioxygenase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q09474-1." [PRO:DNx, UniProtKB:Q09474]
comment: Category=organism-sequence.
synonym: "TDO2/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09474-1
is_a: PR:Q09474 ! tryptophan 2,3-dioxygenase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:A7MBU6
name: tryptophan 2,3-dioxygenase A (zebrafish)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of zebrafish." [OMA:A7MBU6, PRO:DAN]
comment: Category=organism-gene.
synonym: "tdo2" RELATED Gene-based [UniProtKB:A7MBU6]
synonym: "tdo2a" RELATED Gene-based [UniProtKB:A7MBU6]
synonym: "z-TDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TO-A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "TDO-A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "TRPO-A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "tryptophanase A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "tryptophan oxygenase A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "tryptophan pyrrolase A (zebrafish)" EXACT [UniProtKB:A7MBU6]
synonym: "tryptamin 2,3-dioxygenase A (zebrafish)" EXACT [UniProtKB:A7MBU6]
xref: UniProtKB:A7MBU6
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template ZFIN:ZDB-GENE-030131-1187 ! tdo2a (zebrafish)

[Term]
id: PR:P48775
name: tryptophan 2,3-dioxygenase (human)
def: "A tryptophan 2,3-dioxygenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P48775]
comment: Category=organism-gene.
synonym: "TDO" RELATED Gene-based [UniProtKB:P48775]
synonym: "TDO2" RELATED Gene-based [UniProtKB:P48775]
synonym: "hTDO2" EXACT PRO-short-label [PRO:DNx]
synonym: "TO (human)" EXACT [UniProtKB:P48775]
synonym: "TRPO (human)" EXACT [UniProtKB:P48775]
synonym: "tryptophanase (human)" EXACT [UniProtKB:P48775]
synonym: "tryptophan oxygenase (human)" EXACT [UniProtKB:P48775]
synonym: "tryptophan pyrrolase (human)" EXACT [UniProtKB:P48775]
synonym: "tryptamin 2,3-dioxygenase (human)" EXACT [UniProtKB:P48775]
xref: Reactome:R-HSA-71184 "PR:P48775 located_in GO:0005829"
xref: UniProtKB:P48775
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016214 ! tryptophan 2,3-dioxygenase
relationship: has_gene_template HGNC:11708 ! TDO2 (human)

[Term]
id: PR:P21643-1
name: tryptophan 2,3-dioxygenase isoform 1 (rat)
def: "A tryptophan 2,3-dioxygenase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rTDO2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21643-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039566 ! tryptophan 2,3-dioxygenase isoform 1