[Term]
id: PR:P36956
name: sterol regulatory element-binding protein 1 (human)
def: "A sterol regulatory element-binding protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36956]
comment: Category=organism-gene.
synonym: "BHLHD1" RELATED Gene-based [UniProtKB:P36956]
synonym: "SREBF1" RELATED Gene-based [UniProtKB:P36956]
synonym: "SREBP1" RELATED Gene-based [UniProtKB:P36956]
synonym: "hSREBF1" EXACT PRO-short-label [PRO:DNx]
synonym: "SREBP-1 (human)" EXACT [UniProtKB:P36956]
synonym: "class D basic helix-loop-helix protein 1 (human)" EXACT [UniProtKB:P36956]
synonym: "sterol regulatory element-binding transcription factor 1 (human)" EXACT [UniProtKB:P36956]
xref: Reactome:R-HSA-1368141 "PR:P36956 located_in GO:0005789"
xref: UniProtKB:P36956
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015611 ! sterol regulatory element-binding protein 1
relationship: has_gene_template HGNC:11289 ! SREBF1 (human)

[Term]
id: PR:P36956-1
name: sterol regulatory element-binding protein 1 isoform 1 (human)
def: "A sterol regulatory element-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-1
xref: Reactome:R-HSA-1655753 "PR:P36956-1 located_in GO:0000139"
xref: Reactome:R-HSA-1655757 "PR:P36956-1 located_in GO:0005789"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028627 ! sterol regulatory element-binding protein 1 isoform 1

[Term]
id: PR:000045767
name: sterol regulatory element-binding protein 1 phosphorylated 1 (human)
def: "A sterol regulatory element-binding protein 1 (human) that has been phosphorylated at the position equivalent to Ser-117 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Ser-117, MOD:00046." [PMID:10915800, iPTMnet:P36956]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10915800). Status=unreviewed.
synonym: "hSREBF1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36956-1, Ser-117, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36956-3
name: sterol regulatory element-binding protein 1 isoform hSREBP-1C (human)
def: "A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-3." [PRO:DNx, UniProtKB:P36956]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:hSREBP-1C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-3
xref: Reactome:R-HSA-1655760 "PR:P36956-3 located_in GO:0000139"
xref: Reactome:R-HSA-1655761 "PR:P36956-3 located_in GO:0005789"
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36956-2
name: sterol regulatory element-binding protein 1 isoform hSREBP-1B (human)
def: "A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-2." [PRO:DNx, UniProtKB:P36956]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:hSREBP-1B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-2
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36956-5
name: sterol regulatory element-binding protein 1 isoform hSREBP-1aDelta (human)
def: "A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-5." [PRO:DNx, UniProtKB:P36956]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:hSREBP-1aDelta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-5
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36956-4
name: sterol regulatory element-binding protein 1 isoform h4 (human)
def: "A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-4." [PRO:DNx, UniProtKB:P36956]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-4
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000015611
name: sterol regulatory element-binding protein 1
def: "A sterol regulatory element-binding protein that is a translation product of the human SREBF1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "SREBF1" EXACT PRO-short-label [PRO:DNx]
synonym: "SREBP1" RELATED Gene-based []
synonym: "bHLHd1" BROAD [PRO:DNx]
synonym: "SREBP-1" EXACT []
synonym: "class D basic helix-loop-helix protein 1" BROAD [PRO:DNx]
synonym: "sterol regulatory element-binding transcription factor 1" EXACT []
is_a: PR:000028988 ! sterol regulatory element-binding protein

[Term]
id: PR:P36956-6
name: sterol regulatory element-binding protein 1 isoform hSREBP-1cDelta (human)
def: "A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-6." [PRO:DNx, UniProtKB:P36956]
comment: Category=organism-sequence.
synonym: "hSREBF1/iso:hSREBP-1cDelta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36956-6
is_a: PR:P36956 ! sterol regulatory element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028630
name: sterol regulatory element-binding protein 1 isoform 1 acetylated 1 (human)
def: "A sterol regulatory element-binding protein 1 isoform 1 acetylated 1 in human. UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064." [KAT:P36956, PMID:12640139, PRO:PD]
comment: Category=organism-modification. Acetylase=("EP300"; PR:000007102).
synonym: "hSREBF1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028629 ! sterol regulatory element-binding protein 1 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine