[Term]
id: PR:P97698-1
name: smoothened homolog isoform 1 (rat)
def: "A smoothened isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rSMO/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97698-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039833 ! smoothened isoform 1

[Term]
id: PR:000049298
name: smoothened homolog, signal peptide removed phosphorylated 1 (human)
def: "A smoothened homolog (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590 and 595, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632525]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5632525 "PR:000049298 located_in GO:0060170"
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049299
name: smoothened homolog, signal peptide removed phosphorylated 2 (human)
def: "A smoothened homolog (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590, 595, 611, 615 and 616, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632528]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5632528 "PR:000049299 located_in GO:0060170"
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q99835
name: smoothened homolog (human)
def: "A smoothened that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99835]
comment: Category=organism-gene.
synonym: "SMO" RELATED Gene-based [UniProtKB:Q99835]
synonym: "SMOH" RELATED Gene-based [UniProtKB:Q99835]
synonym: "hSMO" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Gx (human)" EXACT [UniProtKB:Q99835]
xref: UniProtKB:Q99835
xref: DTO:02100769
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015288 ! smoothened
relationship: has_gene_template HGNC:11119 ! SMO (human)

[Term]
id: PR:P97698
name: smoothened homolog (rat)
def: "A smoothened that is encoded in the genome of rat." [PANTHER:PTHR11309:SF35, PRO:DNx]
comment: Category=organism-gene.
synonym: "Smo" RELATED Gene-based [UniProtKB:P97698]
synonym: "Smoh" RELATED Gene-based [UniProtKB:P97698]
synonym: "rSMO" EXACT PRO-short-label [PRO:DNx]
synonym: "SMO (rat)" EXACT [UniProtKB:P97698]
xref: UniProtKB:P97698
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000015288 ! smoothened
relationship: has_gene_template RGD:3726 ! Smo (rat)

[Term]
id: PR:P56726
name: smoothened homolog (mouse)
def: "A smoothened that is encoded in the genome of mouse." [OMA:P56726, PRO:DNx]
comment: Category=organism-gene.
synonym: "Smo" RELATED Gene-based [UniProtKB:P56726]
synonym: "Smoh" RELATED Gene-based [UniProtKB:P56726]
synonym: "mSMO" EXACT PRO-short-label [PRO:DNx]
synonym: "SMO (mouse)" EXACT [UniProtKB:P56726]
xref: UniProtKB:P56726
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000015288 ! smoothened
relationship: has_gene_template MGI:108075 ! Smo (mouse)

[Term]
id: PR:000039833
name: smoothened isoform 1
def: "A smoothened that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56726-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "SMO/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000015288 ! smoothened

[Term]
id: PR:000049297
name: smoothened homolog, signal peptide removed form (human)
def: "A smoothened homolog (human) that has had the signal peptide removed. UniProtKB:Q99835, 28-787." [PRO:DNx, Reactome:R-HSA-445121, Reactome:R-HSA-5610419, Reactome:R-HSA-5610422, Reactome:R-HSA-5624094]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-445121 "PR:000049297 located_in GO:0005886"
xref: Reactome:R-HSA-5610419 "PR:000049297 located_in GO:0097542"
xref: Reactome:R-HSA-5610422 "PR:000049297 located_in GO:0030666"
xref: Reactome:R-HSA-5624094 "PR:000049297 located_in GO:0060170"
intersection_of: PR:Q99835 ! smoothened homolog (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56726-1
name: smoothened homolog isoform 1 (mouse)
def: "A smoothened isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mSMO/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P56726-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039833 ! smoothened isoform 1

[Term]
id: PR:000015288
name: smoothened
def: "A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "SMO" EXACT PRO-short-label [PRO:DNx]
synonym: "SMOH" RELATED Gene-based []
synonym: "protein Gx" EXACT []
xref: IUPHARobj:239
is_a: PR:000001315 ! frizzled-like G-protein coupled receptor

[Term]
id: PR:000057981
name: smoothened homolog O-glycosylated 2 (human)
def: "A smoothened homolog (human) that has been O-glycosylated at the residue equivalent to Thr-55 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q99835-1, Thr-55, MOD:00005~GNO:G43417UB." [GlyGen:Q99835-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSMO/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99835-1, Thr-55, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057980
name: smoothened homolog O-glycosylated 1 (human)
def: "A smoothened homolog (human) that has been O-glycosylated at the residue equivalent to Thr-500 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q99835-1, Thr-500, MOD:00005~GNO:G29068FM." [GlyGen:Q99835-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSMO/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99835-1, Thr-500, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057979
name: smoothened homolog N-glycosylated 1 (human)
def: "A smoothened homolog (human) that has been N-glycosylated at the residue equivalent to Asn-35 of the amino acid sequence represented by UniProtKB:Q99835-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:Q99835-1, Asn-35, MOD:00160~GNO:G08293MJ." [GlyGen:Q99835-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSMO/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99835-1, Asn-35, MOD:00160~GNO:G08293MJ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part GNO:G08293MJ ! G08293MJ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P91682
name: protein smoothened (fruit fly)
def: "A smoothened that is encoded in the genome of fruit fly." [PANTHER:PTHR11309:SF35, PRO:DNx]
comment: Category=organism-gene.
synonym: "smo" RELATED Gene-based [UniProtKB:P91682]
synonym: "dSMO" EXACT [UniProtKB:P91682]
synonym: "CG11561" RELATED Gene-based [UniProtKB:P91682]
synonym: "fly-SMO" EXACT PRO-short-label [PRO:DNx]
synonym: "SMOH (fruit fly)" EXACT [UniProtKB:P91682]
synonym: "smooth (fruit fly)" EXACT [UniProtKB:P91682]
xref: UniProtKB:P91682
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000015288 ! smoothened
relationship: has_gene_template FlyBase:FBgn0003444 ! smo (fruit fly)