[Term]
id: PR:000014860
name: E3 ubiquitin-protein ligase SIAH1
def: "A protein that is a translation product of the human SIAH1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "SIAH1" EXACT PRO-short-label [PRO:DNx]
synonym: "Siah-1" EXACT []
synonym: "HUMSIAH" RELATED Gene-based []
synonym: "Siah-1a" EXACT []
synonym: "seven in absentia homolog 1" EXACT []
synonym: "seven in absentia homolog 1a" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8IUQ4-2
name: E3 ubiquitin-protein ligase SIAH1 isoform h2 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-2." [PRO:DNx, UniProtKB:Q8IUQ4]
comment: Category=organism-sequence.
synonym: "hSIAH1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IUQ4-2
is_a: PR:Q8IUQ4 ! E3 ubiquitin-protein ligase SIAH1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IUQ4-3
name: E3 ubiquitin-protein ligase SIAH1 isoform h3 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-3." [PRO:DNx, UniProtKB:Q8IUQ4]
comment: Category=organism-sequence.
synonym: "hSIAH1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "E3 ubiquitin-protein ligase SIAH1 isoform Siah-1S (human)" EXACT [UniProtKB:Q8IUQ4]
xref: UniProtKB:Q8IUQ4-3
is_a: PR:Q8IUQ4 ! E3 ubiquitin-protein ligase SIAH1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025641
name: E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]
comment: Category=organism-modification.
synonym: "hSIAH1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025627 ! E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q8IUQ4-1
name: E3 ubiquitin-protein ligase SIAH1 isoform 1 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSIAH1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IUQ4-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025622 ! E3 ubiquitin-protein ligase SIAH1 isoform 1

[Term]
id: PR:000045369
name: E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 isoform 1 (human) that lacks phosphorylation at Tyr-100 and Tyr-126. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291." [PRO:JAN]
comment: Category=organism-modification.
synonym: "hSIAH1/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8IUQ4-1 ! E3 ubiquitin-protein ligase SIAH1 isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IUQ4
name: E3 ubiquitin-protein ligase SIAH1 (human)
def: "An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IUQ4]
comment: Category=organism-gene.
synonym: "SIAH1" RELATED Gene-based [UniProtKB:Q8IUQ4]
synonym: "hSIAH1" EXACT PRO-short-label [PRO:DNx]
synonym: "HUMSIAH" RELATED Gene-based [UniProtKB:Q8IUQ4]
synonym: "Siah-1 (human)" EXACT [UniProtKB:Q8IUQ4]
synonym: "Siah-1a (human)" EXACT [UniProtKB:Q8IUQ4]
synonym: "seven in absentia homolog 1 (human)" EXACT [UniProtKB:Q8IUQ4]
synonym: "RING-type E3 ubiquitin transferase SIAH1 (human)" EXACT [UniProtKB:Q8IUQ4]
xref: UniProtKB:Q8IUQ4
xref: Reactome:R-HSA-374563 "PR:Q8IUQ4 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014860 ! E3 ubiquitin-protein ligase SIAH1
relationship: has_gene_template HGNC:10857 ! SIAH1 (human)