[Term]
id: PR:000049123
name: ribosomal protein S6 kinase alpha-1 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that has been post-translationally modified to include phosphoserine at positions 221, 363 and 380, and phosphothreonine at position 573 of the amino acid sequence represented by UniProtKB:Q15418. UniProtKB:Q15418, Ser-221/Ser-363/Ser-380, MOD:00046|Thr-573, MOD:00047." [PRO:DNx, Reactome:R-HSA-444292]
comment: Category=organism-modification.
synonym: "hRPS6KA1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15418, Ser-221/Ser-363/Ser-380, MOD:00046|Thr-573, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-444292 "PR:000049123 located_in GO:0005654"
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049124
name: ribosomal protein S6 kinase alpha-1 phosphorylated 2 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that has been post-translationally modified to include phosphoserine at positions 221, 363, 380 and 732, and phosphothreonine at positions 359 and 573 of the amino acid sequence represented by UniProtKB:Q15418. UniProtKB:Q15418, Ser-221/Ser-363/Ser-380/Ser-732, MOD:00046|Thr-359/Thr-573, MOD:00047." [PRO:DNx, Reactome:R-HSA-199829]
comment: Category=organism-modification.
synonym: "hRPS6KA1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15418, Ser-221/Ser-363/Ser-380/Ser-732, MOD:00046|Thr-359/Thr-573, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-199829 "PR:000049124 located_in GO:0005654"
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000014282
name: ribosomal protein S6 kinase alpha-1
def: "A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RSK1" RELATED Gene-based []
synonym: "RSK-1" EXACT []
synonym: "p90S6K" EXACT []
synonym: "RPS6KA1" EXACT PRO-short-label [PRO:DNx]
synonym: "p90RSK1" EXACT []
synonym: "MAPKAPK1A" RELATED Gene-based []
synonym: "p90-RSK 1" EXACT []
synonym: "MAPKAPK-1a" EXACT []
synonym: "S6K-alpha-1" EXACT []
synonym: "MAPKAP kinase 1a" EXACT []
synonym: "ribosomal S6 kinase 1" EXACT []
synonym: "MAPK-activated protein kinase 1a" EXACT []
synonym: "90 kDa ribosomal protein S6 kinase 1" EXACT []
synonym: "MAP kinase-activated protein kinase 1a" EXACT []
xref: IUPHARobj:1527
is_a: PR:000029187 ! ribosomal protein S6 kinase alpha

[Term]
id: PR:000049125
name: obsolete ribosomal protein S6 kinase alpha-1 phosphorylated 3 (human)
def: "OBSOLETE. A ribosomal protein S6 kinase alpha-1 (human) that has been post-translationally modified to include phosphoserine at positions 363 and 380, and phosphothreonine at position 573 of the amino acid sequence represented by UniProtKB:Q15418. UniProtKB:Q15418, Ser-363/Ser-380, MOD:00046|Thr-573, MOD:00047." [PRO:DNx, Reactome:R-HSA-444246, Reactome:R-HSA-445404]
comment: Category (was) organism-modification. Made obsolete since removed from source database. Was cross-referenced to Reactome:R-HSA-444246 and Reactome:R-HSA-445404 (both deprecated).
synonym: "hRPS6KA1/Phos:3" EXACT [PRO:DNx]
synonym: "UniProtKB:Q15418, Ser-363/Ser-380, MOD:00046|Thr-573, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_obsolete: true

[Term]
id: PR:Q15418-4
name: ribosomal protein S6 kinase alpha-1 isoform h4 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-4." [PRO:DNx, UniProtKB:Q15418]
comment: Category=organism-sequence.
synonym: "hRPS6KA1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15418-4
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q15418-2
name: ribosomal protein S6 kinase alpha-1 isoform h2 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-2." [PRO:DNx, UniProtKB:Q15418]
comment: Category=organism-sequence.
synonym: "hRPS6KA1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15418-2
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q15418-3
name: ribosomal protein S6 kinase alpha-1 isoform h3 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-3." [PRO:DNx, UniProtKB:Q15418]
comment: Category=organism-sequence.
synonym: "hRPS6KA1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15418-3
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q15418-1
name: ribosomal protein S6 kinase alpha-1 isoform h1 (human)
def: "A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-1." [PRO:DNx, UniProtKB:Q15418]
comment: Category=organism-sequence.
synonym: "hRPS6KA1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q15418-1
is_a: PR:Q15418 ! ribosomal protein S6 kinase alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q15418
name: ribosomal protein S6 kinase alpha-1 (human)
def: "A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15418]
comment: Category=organism-gene.
synonym: "RSK1" RELATED Gene-based [UniProtKB:Q15418]
synonym: "RPS6KA1" RELATED Gene-based [UniProtKB:Q15418]
synonym: "hRPS6KA1" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPKAPK1A" RELATED Gene-based [UniProtKB:Q15418]
synonym: "RSK-1 (human)" EXACT [UniProtKB:Q15418]
synonym: "p90S6K (human)" EXACT [UniProtKB:Q15418]
synonym: "p90RSK1 (human)" EXACT [UniProtKB:Q15418]
synonym: "p90-RSK 1 (human)" EXACT [UniProtKB:Q15418]
synonym: "MAPKAPK-1a (human)" EXACT [UniProtKB:Q15418]
synonym: "S6K-alpha-1 (human)" EXACT [UniProtKB:Q15418]
synonym: "MAPKAP kinase 1a (human)" EXACT [UniProtKB:Q15418]
synonym: "ribosomal S6 kinase 1 (human)" EXACT [UniProtKB:Q15418]
synonym: "MAPK-activated protein kinase 1a (human)" EXACT [UniProtKB:Q15418]
synonym: "90 kDa ribosomal protein S6 kinase 1 (human)" EXACT [UniProtKB:Q15418]
synonym: "MAP kinase-activated protein kinase 1a (human)" EXACT [UniProtKB:Q15418]
xref: Reactome:R-HSA-199860 "PR:Q15418 located_in GO:0005654"
xref: Reactome:R-HSA-444256 "PR:Q15418 located_in GO:0005829"
xref: DTO:03100251
xref: UniProtKB:Q15418
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014282 ! ribosomal protein S6 kinase alpha-1
relationship: has_gene_template HGNC:10430 ! RPS6KA1 (human)