[Term]
id: PR:Q13905-3
name: Rap guanine nucleotide exchange factor 1 isoform h3 (human)
def: "A Rap guanine nucleotide exchange factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13905-3." [PRO:DNx, UniProtKB:Q13905]
comment: Category=organism-sequence.
synonym: "hRAPGEF1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13905-3
is_a: PR:Q13905 ! Rap guanine nucleotide exchange factor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13905-2
name: Rap guanine nucleotide exchange factor 1 isoform Short (human)
def: "A Rap guanine nucleotide exchange factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13905-2." [PRO:DNx, UniProtKB:Q13905]
comment: Category=organism-sequence.
synonym: "hRAPGEF1/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13905-2
is_a: PR:Q13905 ! Rap guanine nucleotide exchange factor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13905-1
name: Rap guanine nucleotide exchange factor 1 isoform Long (human)
def: "A Rap guanine nucleotide exchange factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13905-1." [PRO:DNx, UniProtKB:Q13905]
comment: Category=organism-sequence.
synonym: "hRAPGEF1/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13905-1
is_a: PR:Q13905 ! Rap guanine nucleotide exchange factor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13905-4
name: Rap guanine nucleotide exchange factor 1 isoform h4 (human)
def: "A Rap guanine nucleotide exchange factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13905-4." [PRO:DNx, UniProtKB:Q13905]
comment: Category=organism-sequence.
synonym: "hRAPGEF1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13905-4
is_a: PR:Q13905 ! Rap guanine nucleotide exchange factor 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000013726
name: Rap guanine nucleotide exchange factor 1
def: "A protein that is a translation product of the human RAPGEF1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GRF2" RELATED Gene-based []
synonym: "RAPGEF1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein C3G" EXACT []
synonym: "CRK SH3-binding GNRP" EXACT []
synonym: "guanine nucleotide-releasing factor 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q3UGX8
name: Rap guanine nucleotide exchange factor 1 isoform 2 (mouse)
def: "A Rap guanine nucleotide exchange factor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UGX8." [PMID:25982384, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mRAPGEF1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "Rapgef1 isoform 2 (mouse)" EXACT []
xref: UniProtKB:Q3UGX8
is_a: PR:Q3UHC1 ! Rap guanine nucleotide exchange factor 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q3UHC1-1
name: Rap guanine nucleotide exchange factor 1 isoform 1 (mouse)
def: "A Rap guanine nucleotide exchange factor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UHC1-1." [PMID:10349636, PMID:33139841, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mRAPGEF1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Rapgef1 isoform 1 (mouse)" EXACT []
xref: UniProtKB:Q3UHC1-1
is_a: PR:Q3UHC1 ! Rap guanine nucleotide exchange factor 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q3UHC1
name: Rap guanine nucleotide exchange factor 1 (mouse)
def: "A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of mouse." [OMA:Q3UHC1, PMID:10349636, PRO:HJD]
comment: Category=organism-gene.
synonym: "mRAPGEF1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q3UHC1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013726 ! Rap guanine nucleotide exchange factor 1
relationship: has_gene_template MGI:104580 ! Rapgef1 (mouse)

[Term]
id: PR:000045924
name: Rap guanine nucleotide exchange factor 1 phosphorylated 1 (human)
def: "A Rap guanine nucleotide exchange factor 1 (human) that has been phosphorylated at the position equivalent to Tyr-504 of the amino acid sequence represented by UniProtKB:Q13905-1. Example: UniProtKB:Q13905-1, Tyr-504, MOD:00048." [PMID:10318861, PMID:14551197, PMID:15320955, PMID:20581864, iPTMnet:Q13905]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10318861, PMID:14551197, PMID:15320955, PMID:20581864). Status=unreviewed.
synonym: "hRAPGEF1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13905-1, Tyr-504, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13905 ! Rap guanine nucleotide exchange factor 1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13905
name: Rap guanine nucleotide exchange factor 1 (human)
def: "A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13905]
comment: Category=organism-gene.
synonym: "GRF2" RELATED Gene-based [UniProtKB:Q13905]
synonym: "RAPGEF1" RELATED Gene-based [UniProtKB:Q13905]
synonym: "hRAPGEF1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein C3G (human)" EXACT [UniProtKB:Q13905]
synonym: "CRK SH3-binding GNRP (human)" EXACT [UniProtKB:Q13905]
synonym: "guanine nucleotide-releasing factor 2 (human)" EXACT [UniProtKB:Q13905]
xref: Reactome:R-HSA-913472 "PR:Q13905 located_in GO:0005829"
xref: Reactome:R-HSA-3008667 "PR:Q13905 located_in GO:0005768"
xref: Reactome:R-HSA-3008672 "PR:Q13905 located_in GO:0005829"
xref: UniProtKB:Q13905
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013726 ! Rap guanine nucleotide exchange factor 1
relationship: has_gene_template HGNC:4568 ! RAPGEF1 (human)

[Term]
id: PR:Q91ZZ2
name: Rap guanine nucleotide exchange factor 1 isoform 3 (mouse)
def: "A Rap guanine nucleotide exchange factor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZZ2." [PMID:25982384, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mRAPGEF1/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "Rapgef1 isoform 3 (mouse)" EXACT []
xref: UniProtKB:Q91ZZ2
is_a: PR:Q3UHC1 ! Rap guanine nucleotide exchange factor 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus