[Term] id: PR:000013239 name: DNA-dependent protein kinase catalytic subunit def: "A protein that is a translation product of the human PRKDC gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HYRC" RELATED Gene-based [] synonym: "p460" BROAD [PRO:DNx] synonym: "DNPK1" EXACT [] synonym: "HYRC1" RELATED Gene-based [] synonym: "PRKDC" EXACT PRO-short-label [PRO:DNx] synonym: "Xrcc7" RELATED Gene-based [] synonym: "DNA-PKcs" EXACT [] synonym: "DNA-PK catalytic subunit" EXACT [] xref: IUPHARobj:2800 is_a: PR:000000001 ! protein [Term] id: PR:P78527-2 name: DNA-dependent protein kinase catalytic subunit isoform h2 (human) def: "A DNA-dependent protein kinase catalytic subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78527-2." [PRO:DNx, UniProtKB:P78527] comment: Category=organism-sequence. synonym: "hPRKDC/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P78527-2 is_a: PR:P78527 ! DNA-dependent protein kinase catalytic subunit (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P78527-1 name: DNA-dependent protein kinase catalytic subunit isoform h1 (human) def: "A DNA-dependent protein kinase catalytic subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78527-1." [PRO:DNx, UniProtKB:P78527] comment: Category=organism-sequence. synonym: "hPRKDC/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P78527-1 is_a: PR:P78527 ! DNA-dependent protein kinase catalytic subunit (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045858 name: DNA-dependent protein kinase catalytic subunit phosphorylated 1 (human) def: "A DNA-dependent protein kinase catalytic subunit (human) that has been phosphorylated at the position equivalent to Thr-2609 of the amino acid sequence represented by UniProtKB:P78527-1. Example: UniProtKB:P78527-1, Thr-2609, MOD:00047." [PMID:12231622, PMID:15507430, iPTMnet:P78527] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12231622, PMID:15507430). Status=unreviewed. synonym: "hPRKDC/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P78527-1, Thr-2609, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P78527 ! DNA-dependent protein kinase catalytic subunit (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P78527 name: DNA-dependent protein kinase catalytic subunit (human) def: "A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human." [PRO:DNx, UniProtKB:P78527] comment: Category=organism-gene. synonym: "HYRC" RELATED Gene-based [UniProtKB:P78527] synonym: "HYRC1" RELATED Gene-based [UniProtKB:P78527] synonym: "PRKDC" RELATED Gene-based [UniProtKB:P78527] synonym: "hPRKDC" EXACT PRO-short-label [PRO:DNx] synonym: "p460 (human)" BROAD [UniProtKB:P78527] synonym: "DNPK1 (human)" EXACT [UniProtKB:P78527] synonym: "DNA-PKcs (human)" EXACT [UniProtKB:P78527] synonym: "DNA-PK catalytic subunit (human)" EXACT [UniProtKB:P78527] xref: Reactome:R-HSA-62161 "PR:P78527 located_in GO:0005654" xref: Reactome:R-HSA-3134816 "PR:P78527 located_in GO:0005829" xref: DTO:03100436 xref: UniProtKB:P78527 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000013239 ! DNA-dependent protein kinase catalytic subunit relationship: has_gene_template HGNC:9413 ! PRKDC (human) [Term] id: PR:000048925 name: DNA-dependent protein kinase catalytic subunit phosphorylated 2 (human) def: "A DNA-dependent protein kinase catalytic subunit (human) that has been post-translationally modified to include phosphothreonine at positions 2609, 2638 and 2647, and phosphoserine at position 2612 of the amino acid sequence represented by UniProtKB:P78527. UniProtKB:P78527, Thr-2609/Thr-2638/Thr-2647, MOD:00047|Ser-2612, MOD:00046." [PRO:DNx, Reactome:R-HSA-76302] comment: Category=organism-modification. synonym: "hPRKDC/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P78527, Thr-2609/Thr-2638/Thr-2647, MOD:00047|Ser-2612, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-76302 "PR:000048925 located_in GO:0005654" is_a: PR:P78527 ! DNA-dependent protein kinase catalytic subunit (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens