[Term]
id: PR:P54645
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of rat." [OMA:P54645, PANTHER:PTHR24343:SF61, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ampk1" RELATED Gene-based [UniProtKB:P54645]
synonym: "Prkaa1" RELATED Gene-based [UniProtKB:P54645]
synonym: "rPRKAA1" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (rat)" RELATED [UniProtKB:P54645]
synonym: "HMGCR kinase (rat)" RELATED [UniProtKB:P54645]
synonym: "AMPK subunit alpha-1 (rat)" EXACT [UniProtKB:P54645]
synonym: "tau-protein kinase PRKAA1 (rat)" EXACT [UniProtKB:P54645]
synonym: "acetyl-CoA carboxylase kinase (rat)" RELATED [UniProtKB:P54645]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (rat)" RELATED [UniProtKB:P54645]
xref: UniProtKB:P54645
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1
relationship: has_gene_template RGD:3387 ! Prkaa1 (rat)

[Term]
id: PR:Q13131-2
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform h2 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13131-2." [PRO:DNx, UniProtKB:Q13131]
comment: Category=organism-sequence.
synonym: "hPRKAA1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13131-2
is_a: PR:Q13131 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5EG47
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of mouse." [OMA:Q5EG47, PRO:DNx]
comment: Category=organism-gene.
synonym: "Prkaa1" RELATED Gene-based [UniProtKB:Q5EG47]
synonym: "mPRKAA1" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (mouse)" RELATED [UniProtKB:Q5EG47]
synonym: "HMGCR kinase (mouse)" RELATED [UniProtKB:Q5EG47]
synonym: "AMPK subunit alpha-1 (mouse)" EXACT [UniProtKB:Q5EG47]
synonym: "tau-protein kinase PRKAA1 (mouse)" EXACT [UniProtKB:Q5EG47]
synonym: "acetyl-CoA carboxylase kinase (mouse)" RELATED [UniProtKB:Q5EG47]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (mouse)" RELATED [UniProtKB:Q5EG47]
xref: UniProtKB:Q5EG47
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1
relationship: has_gene_template MGI:2145955 ! Prkaa1 (mouse)

[Term]
id: PR:000040391
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13131-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PRKAA1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1

[Term]
id: PR:000049972
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 in rat. UniProtKB:P54645, Thr-183, PR:000026291." [PMID:10642499, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10642499).
synonym: "rPRKAA1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P54645, Thr-183, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049970 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1

[Term]
id: PR:000050191
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 in human. Example: UniProtKB:Q13131-1, Thr-183, PR:000026291." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hPRKAA1/UnPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q13131-1, Thr-183, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049970 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1

[Term]
id: PR:P54645-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPRKAA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P54645-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040391 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

[Term]
id: PR:000049968
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 in mouse. UniProtKB:Q5EG47, Thr-183, MOD:00047." [PMID:23842676, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23842676).
synonym: "mPRKAA1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK (Thr(183))" RELATED []
synonym: "UniProtKB:Q5EG47, Thr-183, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049967 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049969
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 (rat)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 in rat. UniProtKB:P54645, Thr-183, MOD:00047." [PMID:10642499, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10642499).
synonym: "rPRKAA1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK (Thr(183))" RELATED []
synonym: "UniProtKB:P54645, Thr-183, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049967 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q13131
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13131]
comment: Category=organism-gene.
synonym: "AMPK1" RELATED Gene-based [UniProtKB:Q13131]
synonym: "PRKAA1" RELATED Gene-based [UniProtKB:Q13131]
synonym: "hPRKAA1" EXACT PRO-short-label [PRO:DNx]
synonym: "ACACA kinase (human)" BROAD [UniProtKB:Q13131]
synonym: "HMGCR kinase (human)" BROAD [UniProtKB:Q13131]
synonym: "AMPK subunit alpha-1 (human)" EXACT [UniProtKB:Q13131]
synonym: "tau-protein kinase PRKAA1 (human)" EXACT [UniProtKB:Q13131]
synonym: "acetyl-CoA carboxylase kinase (human)" BROAD [UniProtKB:Q13131]
synonym: "hydroxymethylglutaryl-CoA reductase kinase (human)" BROAD [UniProtKB:Q13131]
xref: Reactome:R-HSA-380935 "PR:Q13131 located_in GO:0005829"
xref: DTO:03100004
xref: UniProtKB:Q13131
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1
relationship: has_gene_template HGNC:9376 ! PRKAA1 (human)

[Term]
id: PR:Q13131-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKAA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13131-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040391 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

[Term]
id: PR:000048901
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 (human)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 in human. Example: UniProtKB:Q13131-1, Thr-183, MOD:00047." [PRO:CNA, Reactome:R-HSA-2151206, Reactome:R-HSA-380964]
comment: Category=organism-modification.
synonym: "hPRKAA1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13131-1, Thr-183, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-380964 "PR:000048901 located_in GO:0005829"
xref: Reactome:R-HSA-2151206 "PR:000048901 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049967 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049967
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that has been phosphorylated at the position equivalent to Thr-183 of the amino acid sequence represented by UniProtKB:Q13131-1. Example: UniProtKB:Q13131-1, Thr-183, MOD:00047." [PRO:CNA, Reactome:R-HSA-2151206, Reactome:R-HSA-380964]
comment: Category=modification.
synonym: "PRKAA1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q5EG47-1
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPRKAA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5EG47-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040391 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

[Term]
id: PR:000013218
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1
def: "A protein that is a translation product of the human PRKAA1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AMPK1" RELATED Gene-based []
synonym: "PRKAA1" EXACT PRO-short-label [PRO:DNx]
synonym: "AMPK subunit alpha-1" EXACT []
synonym: "tau-protein kinase PRKAA1" EXACT []
xref: IUPHARobj:1541
is_a: PR:000000001 ! protein

[Term]
id: PR:000049971
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 (mouse)
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 in mouse. UniProtKB:Q5EG47, Thr-183, PR:000026291." [PMID:23842676, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23842676).
synonym: "mPRKAA1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q5EG47, Thr-183, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049970 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1

[Term]
id: PR:000049970
name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1
def: "A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that lacks phosphorylation at the position equivalent to Thr-183 of the amino acid sequence represented by UniProtKB:Q13131-1. Example: UniProtKB:Q13131-1, Thr-183, PR:000026291." [PRO:CNA]
comment: Category=modification.
synonym: "PRKAA1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013218 ! 5'-AMP-activated protein kinase catalytic subunit alpha-1