[Term]
id: PR:P14618-1
name: pyruvate kinase PKM isoform M2 (human)
def: "A pyruvate kinase PKM isoform M2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPKM/iso:M2" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM2 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase PKM isoform M2-PK (human)" EXACT [UniProtKB:P14618]
xref: UniProtKB:P14618-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038907 ! pyruvate kinase PKM isoform M2

[Term]
id: PR:000045679
name: pyruvate kinase PKM phosphorylated 1 (human)
def: "A pyruvate kinase PKM (human) that has been phosphorylated at the position equivalent to Ser-37 of the amino acid sequence represented by UniProtKB:P14618-1. Example: UniProtKB:P14618-1, Ser-37, MOD:00046." [PMID:23178880, iPTMnet:P14618]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23178880). Status=unreviewed.
synonym: "hPKM/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P14618-1, Ser-37, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P14618 ! pyruvate kinase PKM (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P14618-2
name: pyruvate kinase PKM isoform M1 (human)
def: "A pyruvate kinase PKM isoform M1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPKM/iso:M1" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM1 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase PKM isoform M1-PK (human)" EXACT [UniProtKB:P14618]
xref: UniProtKB:P14618-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038908 ! pyruvate kinase PKM isoform M1

[Term]
id: PR:P14618-3
name: pyruvate kinase PKM isoform h3 (human)
def: "A pyruvate kinase PKM (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14618-3." [PRO:DNx, UniProtKB:P14618]
comment: Category=organism-sequence.
synonym: "hPKM/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14618-3
is_a: PR:P14618 ! pyruvate kinase PKM (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P14618
name: pyruvate kinase PKM (human)
def: "A pyruvate kinase PKM that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14618]
comment: Category=organism-gene.
synonym: "PK2" RELATED Gene-based [UniProtKB:P14618]
synonym: "PK3" RELATED Gene-based [UniProtKB:P14618]
synonym: "PKM" RELATED Gene-based [UniProtKB:P14618]
synonym: "OIP3" RELATED Gene-based [UniProtKB:P14618]
synonym: "PKM2" RELATED Gene-based [UniProtKB:P14618]
synonym: "hPKM" EXACT PRO-short-label [PRO:DNx]
synonym: "p58 (human)" BROAD [UniProtKB:P14618]
synonym: "CTHBP (human)" EXACT [UniProtKB:P14618]
synonym: "OIP-3 (human)" EXACT [UniProtKB:P14618]
synonym: "THBP1 (human)" EXACT [UniProtKB:P14618]
synonym: "tumor M2-PK (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase 2/3 (human)" EXACT [UniProtKB:P14618]
synonym: "Opa-interacting protein 3 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase muscle isozyme (human)" EXACT [UniProtKB:P14618]
synonym: "thyroid hormone-binding protein 1 (human)" EXACT [UniProtKB:P14618]
synonym: "cytosolic thyroid hormone-binding protein (human)" EXACT [UniProtKB:P14618]
xref: DTO:03100250
xref: UniProtKB:P14618
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template HGNC:9021 ! PKM (human)

[Term]
id: PR:000012783
name: pyruvate kinase PKM
def: "A protein that is a translation product of the human PKM gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PK2" RELATED Gene-based []
synonym: "PK3" RELATED Gene-based []
synonym: "PKM" EXACT PRO-short-label [PRO:DNx]
synonym: "p58" BROAD [PRO:DNx]
synonym: "OIP3" RELATED Gene-based []
synonym: "PKM2" RELATED Gene-based []
synonym: "Pykm" RELATED Gene-based []
synonym: "CTHBP" EXACT []
synonym: "OIP-3" EXACT []
synonym: "THBP1" EXACT []
synonym: "tumor M2-PK" EXACT []
synonym: "pyruvate kinase 2/3" EXACT []
synonym: "Opa-interacting protein 3" EXACT []
synonym: "pyruvate kinase isozymes M1/M2" EXACT []
synonym: "pyruvate kinase muscle isozyme" EXACT []
synonym: "thyroid hormone-binding protein 1" EXACT []
synonym: "cytosolic thyroid hormone-binding protein" EXACT []
is_a: PR:000000001 ! protein