[Term]
id: PR:O62619-1
name: pyruvate kinase isoform A (fruit fly)
def: "A pyruvate kinase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O62619-1." [PRO:DNx, UniProtKB:O62619]
comment: Category=organism-sequence.
synonym: "fly-PKM/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O62619-1
is_a: PR:O62619 ! pyruvate kinase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P14618-2
name: pyruvate kinase PKM isoform M1 (human)
def: "A pyruvate kinase PKM isoform M1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPKM/iso:M1" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM1 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase PKM isoform M1-PK (human)" EXACT [UniProtKB:P14618]
xref: UniProtKB:P14618-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038908 ! pyruvate kinase PKM isoform M1

[Term]
id: PR:O62619-2
name: pyruvate kinase isoform B (fruit fly)
def: "A pyruvate kinase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O62619-2." [PRO:DNx, UniProtKB:O62619]
comment: Category=organism-sequence.
synonym: "fly-PKM/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O62619-2
is_a: PR:O62619 ! pyruvate kinase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P14618-1
name: pyruvate kinase PKM isoform M2 (human)
def: "A pyruvate kinase PKM isoform M2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPKM/iso:M2" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM2 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase PKM isoform M2-PK (human)" EXACT [UniProtKB:P14618]
xref: UniProtKB:P14618-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038907 ! pyruvate kinase PKM isoform M2

[Term]
id: PR:000038907
name: pyruvate kinase PKM isoform M2
def: "A pyruvate kinase PKM that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14618-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PKM/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase isozymes M1/M2 isoform 1" EXACT []
is_a: PR:000012783 ! pyruvate kinase PKM

[Term]
id: PR:000045679
name: pyruvate kinase PKM phosphorylated 1 (human)
def: "A pyruvate kinase PKM (human) that has been phosphorylated at the position equivalent to Ser-37 of the amino acid sequence represented by UniProtKB:P14618-1. Example: UniProtKB:P14618-1, Ser-37, MOD:00046." [PMID:23178880, iPTMnet:P14618]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23178880). Status=unreviewed.
synonym: "hPKM/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P14618-1, Ser-37, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P14618 ! pyruvate kinase PKM (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P52480-2
name: pyruvate kinase PKM isoform M1 (mouse)
def: "A pyruvate kinase PKM isoform M1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPKM/iso:M1" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM1 (mouse)" EXACT [UniProtKB:P52480]
xref: UniProtKB:P52480-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038908 ! pyruvate kinase PKM isoform M1

[Term]
id: PR:000038908
name: pyruvate kinase PKM isoform M1
def: "A pyruvate kinase PKM that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14618-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PKM/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase isozymes M1/M2 isoform 2" EXACT []
is_a: PR:000012783 ! pyruvate kinase PKM

[Term]
id: PR:P00548
name: pyruvate kinase PKM (chicken)
def: "A pyruvate kinase PKM that is encoded in the genome of chicken." [OMA:P00548, PANTHER:PTHR11817:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "PKM" RELATED Gene-based [UniProtKB:P00548]
synonym: "chick-PKM" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00548
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template NCBIGene:396456 ! PKM (chicken)

[Term]
id: PR:P11980-2
name: pyruvate kinase PKM isoform rM2 (rat)
def: "A pyruvate kinase PKM (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11980-2." [PRO:DNx, UniProtKB:P11980]
comment: Category=organism-sequence.
synonym: "rPKM/iso:rM2" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM2 (rat)" EXACT [UniProtKB:P11980]
xref: UniProtKB:P11980-2
is_a: PR:P11980 ! pyruvate kinase PKM (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P11980-1
name: pyruvate kinase PKM isoform M1 (rat)
def: "A pyruvate kinase PKM (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11980-1." [PRO:DNx, UniProtKB:P11980]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "rPkm/iso:M1" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM1 (rat)" EXACT [UniProtKB:P11980]
xref: UniProtKB:P11980-1
is_a: PR:P11980 ! pyruvate kinase PKM (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000020982
name: pyruvate kinase PKM, initiator methionine removed form
def: "A pyruvate kinase PKM that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PKM/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase isozymes M1/M2, initiator methionine removed form" EXACT []
intersection_of: PR:000012783 ! pyruvate kinase PKM
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P11980
name: pyruvate kinase PKM (rat)
def: "A pyruvate kinase PKM that is encoded in the genome of rat." [OMA:P11980, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pkm" RELATED Gene-based [UniProtKB:P11980]
synonym: "Pkm2" RELATED Gene-based [UniProtKB:P11980]
synonym: "Pykm" RELATED Gene-based [UniProtKB:P11980]
synonym: "rPKM" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase muscle isozyme (rat)" EXACT [UniProtKB:P11980]
xref: UniProtKB:P11980
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template RGD:3337 ! Pkm (rat)

[Term]
id: PR:P14618-3
name: pyruvate kinase PKM isoform h3 (human)
def: "A pyruvate kinase PKM (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14618-3." [PRO:DNx, UniProtKB:P14618]
comment: Category=organism-sequence.
synonym: "hPKM/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14618-3
is_a: PR:P14618 ! pyruvate kinase PKM (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P14618
name: pyruvate kinase PKM (human)
def: "A pyruvate kinase PKM that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14618]
comment: Category=organism-gene.
synonym: "PK2" RELATED Gene-based [UniProtKB:P14618]
synonym: "PK3" RELATED Gene-based [UniProtKB:P14618]
synonym: "PKM" RELATED Gene-based [UniProtKB:P14618]
synonym: "OIP3" RELATED Gene-based [UniProtKB:P14618]
synonym: "PKM2" RELATED Gene-based [UniProtKB:P14618]
synonym: "hPKM" EXACT PRO-short-label [PRO:DNx]
synonym: "p58 (human)" BROAD [UniProtKB:P14618]
synonym: "CTHBP (human)" EXACT [UniProtKB:P14618]
synonym: "OIP-3 (human)" EXACT [UniProtKB:P14618]
synonym: "THBP1 (human)" EXACT [UniProtKB:P14618]
synonym: "tumor M2-PK (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase 2/3 (human)" EXACT [UniProtKB:P14618]
synonym: "Opa-interacting protein 3 (human)" EXACT [UniProtKB:P14618]
synonym: "pyruvate kinase muscle isozyme (human)" EXACT [UniProtKB:P14618]
synonym: "thyroid hormone-binding protein 1 (human)" EXACT [UniProtKB:P14618]
synonym: "cytosolic thyroid hormone-binding protein (human)" EXACT [UniProtKB:P14618]
xref: DTO:03100250
xref: UniProtKB:P14618
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template HGNC:9021 ! PKM (human)

[Term]
id: PR:P52480
name: pyruvate kinase PKM (mouse)
def: "A pyruvate kinase PKM that is encoded in the genome of mouse." [OMA:P52480, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pk3" RELATED Gene-based [UniProtKB:P52480]
synonym: "Pkm" RELATED Gene-based [UniProtKB:P52480]
synonym: "Pkm2" RELATED Gene-based [UniProtKB:P52480]
synonym: "Pykm" RELATED Gene-based [UniProtKB:P52480]
synonym: "mPKM" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase muscle isozyme (mouse)" EXACT [UniProtKB:P52480]
xref: UniProtKB:P52480
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template MGI:97591 ! Pkm (mouse)

[Term]
id: PR:000012783
name: pyruvate kinase PKM
def: "A protein that is a translation product of the human PKM gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PK2" RELATED Gene-based []
synonym: "PK3" RELATED Gene-based []
synonym: "PKM" EXACT PRO-short-label [PRO:DNx]
synonym: "p58" BROAD [PRO:DNx]
synonym: "OIP3" RELATED Gene-based []
synonym: "PKM2" RELATED Gene-based []
synonym: "Pykm" RELATED Gene-based []
synonym: "CTHBP" EXACT []
synonym: "OIP-3" EXACT []
synonym: "THBP1" EXACT []
synonym: "tumor M2-PK" EXACT []
synonym: "pyruvate kinase 2/3" EXACT []
synonym: "Opa-interacting protein 3" EXACT []
synonym: "pyruvate kinase isozymes M1/M2" EXACT []
synonym: "pyruvate kinase muscle isozyme" EXACT []
synonym: "thyroid hormone-binding protein 1" EXACT []
synonym: "cytosolic thyroid hormone-binding protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O62619
name: pyruvate kinase (fruit fly)
def: "A pyruvate kinase PKM that is encoded in the genome of fruit fly." [PANTHER:PTHR11817:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "PyK" RELATED Gene-based [UniProtKB:O62619]
synonym: "CG7070" RELATED Gene-based [UniProtKB:O62619]
synonym: "fly-PKM" EXACT PRO-short-label [PRO:DNx]
synonym: "PK (fruit fly)" EXACT [UniProtKB:O62619]
xref: UniProtKB:O62619
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000012783 ! pyruvate kinase PKM
relationship: has_gene_template FlyBase:FBgn0267385 ! PyK (fruit fly)

[Term]
id: PR:P52480-1
name: pyruvate kinase PKM isoform M2 (mouse)
def: "A pyruvate kinase PKM isoform M2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPKM/iso:M2" EXACT PRO-short-label [PRO:DNx]
synonym: "pyruvate kinase PKM isoform PKM2 (mouse)" EXACT [UniProtKB:P52480]
xref: UniProtKB:P52480-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038907 ! pyruvate kinase PKM isoform M2