[Term]
id: PR:P70266-2
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform m2 (mouse)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70266-2." [PRO:DNx, UniProtKB:P70266]
comment: Category=organism-sequence.
synonym: "mPFKFB1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70266-2
is_a: PR:P70266 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P16118
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "F6PK" RELATED Gene-based [UniProtKB:P16118]
synonym: "PFRX" RELATED Gene-based [UniProtKB:P16118]
synonym: "PFKFB1" RELATED Gene-based [UniProtKB:P16118]
synonym: "hPFKFB1" EXACT PRO-short-label [PRO:DNx]
synonym: "PFK/FBPase 1 (human)" EXACT [UniProtKB:P16118]
synonym: "6PF-2-K/Fru-2,6-P2ase 1 (human)" EXACT [UniProtKB:P16118]
synonym: "6PF-2-K/Fru-2,6-P2ase liver isozyme (human)" EXACT [UniProtKB:P16118]
xref: DTO:03100630
xref: UniProtKB:P16118
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012578 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
relationship: has_gene_template HGNC:8872 ! PFKFB1 (human)

[Term]
id: PR:000012578
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase that is a translation product of the human PFKFB1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "F6PK" RELATED Gene-based []
synonym: "PFRX" RELATED Gene-based []
synonym: "PFKFB1" EXACT PRO-short-label [PRO:DNx]
synonym: "PFK/FBPase 1" EXACT []
synonym: "6PF-2-K/Fru-2,6-P2ase 1" EXACT []
synonym: "6PF-2-K/Fru-2,6-P2ase liver isozyme" EXACT []
is_a: PR:000029977 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

[Term]
id: PR:000026776
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated 1 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated 1 in human. Example: UniProtKB:P16118-1, 2-471, Ser-33, MOD:00046." [PRO:DAN, Reactome:R-HSA-163749]
comment: Category=organism-modification.
synonym: "hPFKFB1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000179960, Ser-33, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P16118-1, 2-471, Ser-33, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-163749 "PR:000026776 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026775 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026774
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated form
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that has had the initiator methionine removed and that includes at least one phosphorylated residue." [PRO:DAN]
comment: Category=modification.
synonym: "PFKFB1/InitMet-/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000012578 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026775
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated 1
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated form in which the phosphorylation occurs at the serine in the N-terminal RRGS motif. Example: UniProtKB:P16118-1, 2-471, Ser-33, MOD:00046." [PRO:DAN]
comment: Category=modification.
synonym: "PFKFB1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00046 ! O-phospho-L-serine
intersection_of: PR:000026774 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed phosphorylated form

[Term]
id: PR:P16118-2
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform h2 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16118-2." [PRO:DNx, UniProtKB:P16118]
comment: Category=organism-sequence.
synonym: "hPFKFB1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16118-2
is_a: PR:P16118 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70266
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (mouse)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of mouse." [OMA:P70266, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pfkfb1" RELATED Gene-based [UniProtKB:P70266]
synonym: "mPFKFB1" EXACT PRO-short-label [PRO:DNx]
synonym: "PFK/FBPase 1 (mouse)" EXACT [UniProtKB:P70266]
synonym: "6PF-2-K/Fru-2,6-P2ase 1 (mouse)" EXACT [UniProtKB:P70266]
synonym: "6PF-2-K/Fru-2,6-P2ase liver isozyme (mouse)" EXACT [UniProtKB:P70266]
xref: UniProtKB:P70266
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012578 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
relationship: has_gene_template MGI:107816 ! Pfkfb1 (mouse)

[Term]
id: PR:000038947
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16118-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PFKFB1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000012578 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

[Term]
id: PR:P07953-2
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform r2 (rat)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07953-2." [PRO:DNx, UniProtKB:P07953]
comment: Category=organism-sequence.
synonym: "rPFKFB1/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07953-2
is_a: PR:P07953 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P07953
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (rat)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of rat." [OMA:P07953, PANTHER:PTHR10606:SF15, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pfkfb1" RELATED Gene-based [UniProtKB:P07953]
synonym: "rPFKFB1" EXACT PRO-short-label [PRO:DNx]
synonym: "PFK/FBPase 1 (rat)" EXACT [UniProtKB:P07953]
synonym: "6PF-2-K/Fru-2,6-P2ase 1 (rat)" EXACT [UniProtKB:P07953]
synonym: "6PF-2-K/Fru-2,6-P2ase liver isozyme (rat)" EXACT [UniProtKB:P07953]
xref: UniProtKB:P07953
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012578 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
relationship: has_gene_template RGD:3307 ! Pfkfb1 (rat)

[Term]
id: PR:P07953-1
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 (rat)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPFKFB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07953-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038947 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

[Term]
id: PR:P16118-1
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPFKFB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16118-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038947 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

[Term]
id: PR:000042034
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, initiator methionine removed form (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human) that has had the initiator methionine removed. Example: UniProtKB:P16118-1, 2-471." [PRO:DAN]
comment: Category=organism-modification.
synonym: "PRO_0000179960" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hPFKFB1/InitMet-" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P16118-1, 2-471" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-71785 "PR:000042034 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P16118 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70266-1
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 (mouse)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPFKFB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70266-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038947 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1