[Term]
id: PR:000044826
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on a Ser residue equivalent to Ser-232 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
comment: Category=organism-modification. Kinase=("PDK1"; PR:Q15118; Ser-232). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-232, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-232, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044827
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 2 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on a Ser residue equivalent to Ser-293 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
comment: Category=organism-modification. Kinase=("PDK1"; PR:Q15118; Ser-293). Kinase=("PDK2"; PR:Q15119; Ser-293). Kinase=("PDK3"; PR:Q15120; Ser-293). Kinase=("PDK4"; PR:Q16654; Ser-293). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-293, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044833
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 5 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been found to be phosphorylated on a Ser residue equivalent to Ser-293, and unphosphorylated on a Ser residue equivalent to Ser-300 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046|Ser-300, PR:000026291." [CPTAC:breast_cancer_dataset, PRO:AEL]
comment: Category=organism-modification. Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:5" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-293, MOD:00046|Ser-300, PR:000026291" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-293, MOD:00046|Ser-300, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044832
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 4 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on two Ser residues equivalent to Ser-293 and Ser-300 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293/Ser-300, MOD:00046." [CPTAC:breast_cancer_dataset, PRO:AEL]
comment: Category=organism-modification. Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:4" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-293/Ser-300, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-293/Ser-300, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044835
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form in human. Example: UniProtKB:P08559-1, 31-390." [PMID:23146587, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000020440" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hPDHA1/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-69966 "PR:000044835 located_in GO:0005759"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000020907 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form
relationship: lacks_part SO:0000725 ! transit_peptide

[Term]
id: PR:000044834
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 6 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been found to be unphosphorylated on a Ser residue equivalent to Ser-293, and phosphorylated on a Ser residue equivalent to Ser-300 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-293, PR:000026291|Ser-300, MOD:00046." [CPTAC:breast_cancer_dataset, PRO:AEL]
comment: Category=organism-modification. Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:6" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-293, PR:000026291|Ser-300, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-293, PR:000026291|Ser-300, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08559
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08559]
comment: Category=organism-gene.
synonym: "PDHA1" RELATED Gene-based [UniProtKB:P08559]
synonym: "PHE1A" RELATED Gene-based [UniProtKB:P08559]
synonym: "hPDHA1" EXACT PRO-short-label [PRO:DNx]
synonym: "PDHE1-A type I (human)" EXACT [UniProtKB:P08559]
xref: UniProtKB:P08559
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012493 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
relationship: has_gene_template HGNC:8806 ! PDHA1 (human)

[Term]
id: PR:000044828
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on a Ser residue equivalent to Ser-300 in UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
comment: Category=organism-modification. Kinase=("PDK1"; PR:Q15118; Ser-300). Kinase=("PDK2"; PR:Q15119; Ser-300). Kinase=("PDK3"; PR:Q15120; Ser-300). Kinase=("PDK4"; PR:Q16654; Ser-300). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:3" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000020440, Ser-300, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044829
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial inactive (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) whose pyruvate dehydrogenase activity has been inhibited." [PMID:11485553, PMID:19341700, PMID:7782287, PRO:AEL]
comment: Category=union.
synonym: "hPDHA1/TransPep-/Phos:[123]" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
union_of: PR:000044826 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 1 (human)
union_of: PR:000044827 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 2 (human)
union_of: PR:000044828 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08559-4
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h4 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-4." [PRO:DNx, UniProtKB:P08559]
comment: Category=organism-sequence.
synonym: "hPDHA1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08559-4
is_a: PR:P08559 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012493
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
def: "A protein that is a translation product of the human PDHA1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PDHA1" EXACT PRO-short-label [PRO:DNx]
synonym: "PHE1A" RELATED Gene-based []
synonym: "Pdha-1" RELATED Gene-based []
synonym: "PDHE1-A type I" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P08559-3
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h3 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-3." [PRO:DNx, UniProtKB:P08559]
comment: Category=organism-sequence.
synonym: "hPDHA1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08559-3
is_a: PR:P08559 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08559-2
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform h2 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08559-2." [PRO:DNx, UniProtKB:P08559]
comment: Category=organism-sequence.
synonym: "hPDHA1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08559-2
is_a: PR:P08559 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08559-1
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPDHA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08559-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038740 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1