[Term]
id: PR:000012239
name: serine/threonine-protein kinase PAK 1
def: "A protein that is a translation product of the human PAK1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PAK1" EXACT PRO-short-label [PRO:DNx]
synonym: "Paka" RELATED Gene-based []
synonym: "PAK-1" EXACT []
synonym: "p65-PAK" EXACT []
synonym: "alpha-PAK" EXACT []
synonym: "p21-activated kinase 1" EXACT []
synonym: "CDC42/RAC effector kinase PAK-A" EXACT []
xref: IUPHARobj:2133
is_a: PR:000000001 ! protein

[Term]
id: PR:Q13153-2
name: serine/threonine-protein kinase PAK 1 isoform h2 (human)
def: "A serine/threonine-protein kinase PAK 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13153-2." [PRO:DNx, UniProtKB:Q13153]
comment: Category=organism-sequence.
synonym: "hPAK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase PAK 1 isoform PAK1B (human)" EXACT [UniProtKB:Q13153]
xref: UniProtKB:Q13153-2
is_a: PR:Q13153 ! serine/threonine-protein kinase PAK 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13153-1
name: serine/threonine-protein kinase PAK 1 isoform 1 (human)
def: "A serine/threonine-protein kinase PAK 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13153-1." [PRO:DNx, UniProtKB:Q13153]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPAK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13153-1
is_a: PR:Q13153 ! serine/threonine-protein kinase PAK 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035776
name: serine/threonine-protein kinase PAK 1 phosphorylated 1 (human)
def: "A serine/threonine-protein kinase PAK 1 phosphorylated 1 in human. UniProtKB:Q13153, Thr-423, MOD:00047." [PMID:22369945, PRO:IC]
comment: Category=organism-modification.
synonym: "hPAK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13153, Thr-423, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035775 ! serine/threonine-protein kinase PAK 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000048688
name: serine/threonine-protein kinase PAK 1 phosphorylated 4 (human)
def: "A serine/threonine-protein kinase PAK 1 (human) that has been post-translationally modified to include phosphoserine at position 144, and phosphothreonine at position 423 of the amino acid sequence represented by UniProtKB:Q13153. UniProtKB:Q13153, Ser-144, MOD:00046|Thr-423, MOD:00047." [PRO:DNx, Reactome:R-HSA-3928472, Reactome:R-HSA-399819]
comment: Category=organism-modification.
synonym: "hPAK1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13153, Ser-144, MOD:00046|Thr-423, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-399819 "PR:000048688 located_in GO:0005829"
xref: Reactome:R-HSA-3928472 "PR:000048688 located_in GO:0005886"
is_a: PR:Q13153 ! serine/threonine-protein kinase PAK 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045900
name: serine/threonine-protein kinase PAK 1 phosphorylated 2 (human)
def: "A serine/threonine-protein kinase PAK 1 (human) that has been phosphorylated at the position equivalent to Ser-174 of the amino acid sequence represented by UniProtKB:Q13153-1. Example: UniProtKB:Q13153-1, Ser-174, MOD:00046." [PMID:19520772, iPTMnet:Q13153]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19520772). Status=unreviewed.
synonym: "hPAK1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13153-1, Ser-174, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13153 ! serine/threonine-protein kinase PAK 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13153
name: serine/threonine-protein kinase PAK 1 (human)
def: "A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13153]
comment: Category=organism-gene.
synonym: "PAK1" RELATED Gene-based [UniProtKB:Q13153]
synonym: "hPAK1" EXACT PRO-short-label [PRO:DNx]
synonym: "PAK-1 (human)" BROAD [UniProtKB:Q13153]
synonym: "p65-PAK (human)" EXACT [UniProtKB:Q13153]
synonym: "alpha-PAK (human)" EXACT [UniProtKB:Q13153]
synonym: "p21-activated kinase 1 (human)" EXACT [UniProtKB:Q13153]
xref: Reactome:R-HSA-162629 "PR:Q13153 located_in GO:0005829"
xref: Reactome:R-HSA-3928409 "PR:Q13153 located_in GO:0005886"
xref: Reactome:R-HSA-8964622 "PR:Q13153 located_in GO:0005829"
xref: DTO:03100384
xref: UniProtKB:Q13153
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012239 ! serine/threonine-protein kinase PAK 1
relationship: has_gene_template HGNC:8590 ! PAK1 (human)

[Term]
id: PR:000048687
name: serine/threonine-protein kinase PAK 1 phosphorylated 3 (human)
def: "A serine/threonine-protein kinase PAK 1 (human) that has been post-translationally modified to include phosphoserine at position 144 of the amino acid sequence represented by UniProtKB:Q13153. UniProtKB:Q13153, Ser-144, MOD:00046." [PRO:DNx, Reactome:R-HSA-451339]
comment: Category=organism-modification.
synonym: "hPAK1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13153, Ser-144, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-451339 "PR:000048687 located_in GO:0005829"
is_a: PR:Q13153 ! serine/threonine-protein kinase PAK 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens