[Term]
id: PR:Q9P786
name: methylenetetrahydrofolate dehydrogenase [NAD(+)] (Schizosaccharomyces pombe 972h-)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]
comment: Category=organism-gene.
synonym: "mtd1" RELATED Gene-based [UniProtKB:Q9P786]
synonym: "SPBC1711.04" RELATED Gene-based [UniProtKB:Q9P786]
synonym: "Spom972h-MTHFD2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9P786
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
relationship: has_gene_template PomBase:SPBC1711.04 ! mtd1 (Schizosaccharomyces pombe)

[Term]
id: PR:P13995
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P13995]
comment: Category=organism-gene.
synonym: "NMDMC" RELATED Gene-based [UniProtKB:P13995]
synonym: "MTHFD2" RELATED Gene-based [UniProtKB:P13995]
synonym: "hMTHFD2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P13995
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
relationship: has_gene_template HGNC:7434 ! MTHFD2 (human)

[Term]
id: PR:Q5ZKA5
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (chicken)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of chicken." [OMA:Q5ZKA5, PANTHER:PTHR10025:SF17, PRO:DNx]
comment: Category=organism-gene.
synonym: "MTHFD2" RELATED Gene-based [UniProtKB:Q5ZKA5]
synonym: "RCJMB04_12b8" RELATED Gene-based [UniProtKB:Q5ZKA5]
synonym: "chick-MTHFD2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5ZKA5
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
relationship: has_gene_template NCBIGene:426126 ! MTHFD2 (chicken)

[Term]
id: PR:P13995-2
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform h2 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13995-2." [PRO:DNx, UniProtKB:P13995]
comment: Category=organism-sequence.
synonym: "hMTHFD2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P13995-2
is_a: PR:P13995 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P13995-1
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1 (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMTHFD2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P13995-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038895 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1

[Term]
id: PR:000038895
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13995-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "MTHFD2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

[Term]
id: PR:P18155-1
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1 (mouse)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mMTHFD2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18155-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038895 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform 1

[Term]
id: PR:000020648
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, transit peptide removed form
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that has had the transit peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "MTHFD2/TransPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
intersection_of: lacks_part SO:0000725 ! transit_peptide

[Term]
id: PR:P18155
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (mouse)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of mouse." [OMA:P18155, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nmdmc" RELATED Gene-based [UniProtKB:P18155]
synonym: "Mthfd2" RELATED Gene-based [UniProtKB:P18155]
synonym: "mMTHFD2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18155
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010724 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
relationship: has_gene_template MGI:1338850 ! Mthfd2 (mouse)

[Term]
id: PR:000010724
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
def: "A protein that is a translation product of the human MTHFD2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NMDMC" RELATED Gene-based []
synonym: "MTHFD2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:000048470
name: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, transit peptide removed form (human)
def: "A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P13995, 36-350." [PRO:DNx, Reactome:R-HSA-6801347]
comment: Category=organism-modification.
synonym: "PRO_0000034049" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMTHFD2/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P13995, 36-350" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6801347 "PR:000048470 located_in GO:0005759"
intersection_of: PR:P13995 ! bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens