[Term]
id: PR:000048383
name: MAP kinase-interacting serine/threonine-protein kinase 1 phosphorylated 1 (human)
def: "A MAP kinase-interacting serine/threonine-protein kinase 1 (human) that has been post-translationally modified to include phosphothreonine at positions 250, 255 and 385, and phosphoserine at position 437 of the amino acid sequence represented by UniProtKB:Q9BUB5. UniProtKB:Q9BUB5, Thr-250/Thr-255/Thr-385, MOD:00047|Ser-437, MOD:00046." [PRO:DNx, Reactome:R-HSA-947860]
comment: Category=organism-modification.
synonym: "hMKNK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9BUB5, Thr-250/Thr-255/Thr-385, MOD:00047|Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-947860 "PR:000048383 located_in GO:0005829"
is_a: PR:Q9BUB5 ! MAP kinase-interacting serine/threonine-protein kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9BUB5
name: MAP kinase-interacting serine/threonine-protein kinase 1 (human)
def: "A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9BUB5]
comment: Category=organism-gene.
synonym: "MNK1" RELATED Gene-based [UniProtKB:Q9BUB5]
synonym: "MKNK1" RELATED Gene-based [UniProtKB:Q9BUB5]
synonym: "hMKNK1" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPK signal-integrating kinase 1 (human)" EXACT [UniProtKB:Q9BUB5]
synonym: "MAP kinase signal-integrating kinase 1 (human)" EXACT [UniProtKB:Q9BUB5]
xref: UniProtKB:Q9BUB5
xref: DTO:03100328
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010429 ! MAP kinase-interacting serine/threonine-protein kinase 1
relationship: has_gene_template HGNC:7110 ! MKNK1 (human)

[Term]
id: PR:000010429
name: MAP kinase-interacting serine/threonine-protein kinase 1
def: "A protein that is a translation product of the human MKNK1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MNK1" RELATED Gene-based []
synonym: "mnk1" EXACT []
synonym: "MKNK1" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPK signal-integrating kinase 1" EXACT []
synonym: "MAP kinase signal-integrating kinase 1" EXACT []
xref: IUPHARobj:2104
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9BUB5-2
name: MAP kinase-interacting serine/threonine-protein kinase 1 isoform h2 (human)
def: "A MAP kinase-interacting serine/threonine-protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BUB5-2." [PRO:DNx, UniProtKB:Q9BUB5]
comment: Category=organism-sequence.
synonym: "hMKNK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "MAP kinase-interacting serine/threonine-protein kinase 1 isoform MNK1a (human)" EXACT [UniProtKB:Q9BUB5]
xref: UniProtKB:Q9BUB5-2
is_a: PR:Q9BUB5 ! MAP kinase-interacting serine/threonine-protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9BUB5-3
name: MAP kinase-interacting serine/threonine-protein kinase 1 isoform h3 (human)
def: "A MAP kinase-interacting serine/threonine-protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BUB5-3." [PRO:DNx, UniProtKB:Q9BUB5]
comment: Category=organism-sequence.
synonym: "hMKNK1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "MAP kinase-interacting serine/threonine-protein kinase 1 isoform MNK1b (human)" EXACT [UniProtKB:Q9BUB5]
xref: UniProtKB:Q9BUB5-3
is_a: PR:Q9BUB5 ! MAP kinase-interacting serine/threonine-protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9BUB5-1
name: MAP kinase-interacting serine/threonine-protein kinase 1 isoform h1 (human)
def: "A MAP kinase-interacting serine/threonine-protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BUB5-1." [PRO:DNx, UniProtKB:Q9BUB5]
comment: Category=organism-sequence.
synonym: "hMKNK1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9BUB5-1
is_a: PR:Q9BUB5 ! MAP kinase-interacting serine/threonine-protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens